Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
hypAHydrogenase nickel insertion protein HypA; Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase. (127 aa)    
Predicted Functional Partners:
ACV24803.1
TIGRFAM: hydrogenase accessory protein HypB; PFAM: cobalamin synthesis protein P47K; KEGG: hch:HCH_00076 hydrogenase accessory protein HypB.
 
 
 0.984
ACV24292.1
PFAM: Protein of unknown function DUF54.
 
    0.977
ACV24079.1
PFAM: nickel-dependent hydrogenase large subunit; KEGG: dps:DP1013 methylviologen-reducing hydrogenase, alpha chain.
  
 
 0.943
ACV25051.1
Contains selenocysteine; TIGRFAM: coenzyme F420 hydrogenase, subunit alpha; PFAM: nickel-dependent hydrogenase large subunit; KEGG: gem:GM21_3972 nickel-dependent hydrogenase large subunit; Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family.
 
 
 0.941
ACV25298.1
TIGRFAM: hydrogenase expression/formation protein HypD; PFAM: hydrogenase formation HypD protein; KEGG: dal:Dalk_2011 hydrogenase expression/formation protein HypD.
 
  
 0.938
ACV24246.1
ATPase-like, ParA/MinD; Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP; Belongs to the Mrp/NBP35 ATP-binding proteins family.
   
 
 0.921
ACV24887.1
TIGRFAM: [NiFe] hydrogenase maturation protein HypF; PFAM: SUA5/yciO/yrdC domain; acylphosphatase; zinc finger HypF domain protein; KEGG: abu:Abu_1423 transcriptional regulatory protein HypF.
 
   
 0.920
ACV24444.1
TIGRFAM: hydrogenase expression/formation protein HypE; PFAM: AIR synthase related protein domain protein; AIR synthase related protein; KEGG: afw:Anae109_0515 hydrogenase expression/formation protein HypE.
 
  
 0.907
ACV24978.1
PFAM: cobalamin synthesis protein P47K; KEGG: glo:Glov_1036 cobalamin synthesis protein P47K.
  
 
 0.874
ACV24304.1
TIGRFAM: hydrogenase assembly chaperone hypC/hupF; PFAM: hydrogenase expression/formation protein (HUPF/HYPC); KEGG: wsu:WS0792 hydrogenase expression/formation protein.
  
  
 0.827
Your Current Organism:
Methanocaldococcus fervens
NCBI taxonomy Id: 573064
Other names: M. fervens AG86, Methanocaldococcus fervens AG86, Methanocaldococcus fervens DSM 4213, Methanocaldococcus fervens str. AG86, Methanocaldococcus fervens strain AG86
Server load: low (16%) [HD]