Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
ACV24294.1PFAM: NAD-dependent epimerase/dehydratase; 3-beta hydroxysteroid dehydrogenase/isomerase; Male sterility domain; polysaccharide biosynthesis protein CapD; dTDP-4-dehydrorhamnose reductase; KEGG: mxa:MXAN_3507 UDP-glucose 4-epimerase. (304 aa)    
Predicted Functional Partners:
ACV24347.1
Nucleotide sugar dehydrogenase; KEGG: mxa:MXAN_1048 UDP-glucose 6-dehydrogenase; TIGRFAM: nucleotide sugar dehydrogenase; PFAM: UDP-glucose/GDP-mannose dehydrogenase; UDP-glucose/GDP-mannose dehydrogenase dimerization; UDP-glucose/GDP-mannose dehydrogenase; NAD-dependent glycerol-3-phosphate dehydrogenase domain protein.
 
 0.946
sucC
succinyl-CoA synthetase, beta subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
  
 
 0.932
ACV24355.1
TIGRFAM: UTP-glucose-1-phosphate uridylyltransferase; PFAM: Nucleotidyl transferase; KEGG: gme:Gmet_1159 UDP-glucose pyrophosphorylase.
  
 
 0.924
ACV24598.1
PFAM: Nucleotidyl transferase; transferase hexapeptide repeat containing protein; KEGG: fph:Fphi_0366 UDP-N-acetylglucosamine pyrophosphorylase/glucosamine-1-phosphate N-acetyltransferase.
 
 0.923
rps12
Ribosomal protein S23 (S12); With S4 and S5 plays an important role in translational accuracy. Located at the interface of the 30S and 50S subunits. Belongs to the universal ribosomal protein uS12 family.
 
 0.914
rps19p
Ribosomal protein S19; Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.
  
 0.909
rps3
Ribosomal protein S3; Binds the lower part of the 30S subunit head. Belongs to the universal ribosomal protein uS3 family.
  
 0.904
rps3ae
PFAM: ribosomal protein S3Ae; KEGG: hypothetical protein; Belongs to the eukaryotic ribosomal protein eS1 family.
  
 0.904
rps10
Ribosomal protein S10; Involved in the binding of tRNA to the ribosomes. Belongs to the universal ribosomal protein uS10 family.
 
 0.903
rps28e
PFAM: Ribosomal protein S28e; KEGG: 40S ribosomal protein S28; K02979 small subunit ribosomal protein S28e; Belongs to the eukaryotic ribosomal protein eS28 family.
   
 0.902
Your Current Organism:
Methanocaldococcus fervens
NCBI taxonomy Id: 573064
Other names: M. fervens AG86, Methanocaldococcus fervens AG86, Methanocaldococcus fervens DSM 4213, Methanocaldococcus fervens str. AG86, Methanocaldococcus fervens strain AG86
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