Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
ACV24366.1PFAM: protein of unknown function DUF343; KEGG: hch:HCH_02705 hypothetical protein. (50 aa)    
Predicted Functional Partners:
ACV24367.1
2'-5' RNA ligase; Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester; Belongs to the 2H phosphoesterase superfamily. ThpR family.
       0.927
ACV24368.1
KEGG: hypothetical protein.
       0.918
ACV24369.1
KEGG: predicted protein.
       0.918
ACV24364.1
PFAM: N-6 DNA methylase; restriction modification system DNA specificity domain; KEGG: wsu:WS1649 DNA methylase-type I restriction-modification system.
       0.565
ACV24365.1
KEGG: hypothetical protein.
       0.565
ACV24936.1
PFAM: histidine triad (HIT) protein; KEGG: HIT family protein.
  
    0.535
pyrG
CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
     
 0.514
purA
Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family.
       0.501
cobD
Cobalamin biosynthesis protein CobD; Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group.
       0.454
ACV24417.1
TIGRFAM: methylase; PFAM: methyltransferase small; Methyltransferase type 11; Methyltransferase type 12; KEGG: hypothetical protein.
  
 
 0.444
Your Current Organism:
Methanocaldococcus fervens
NCBI taxonomy Id: 573064
Other names: M. fervens AG86, Methanocaldococcus fervens AG86, Methanocaldococcus fervens DSM 4213, Methanocaldococcus fervens str. AG86, Methanocaldococcus fervens strain AG86
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