Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
ACV24388.1PFAM: pyridine nucleotide-disulphide oxidoreductase dimerization region; FAD-dependent pyridine nucleotide-disulphide oxidoreductase; KEGG: afw:Anae109_0766 FAD-dependent pyridine nucleotide-disulphide oxidoreductase. (447 aa)    
Predicted Functional Partners:
ACV24854.1
PFAM: DsrE family protein; SirA family protein; KEGG: pca:Pcar_0429 uncharacterized NAD(FAD)-dependent dehydrogenase.
 
   
 0.958
ACV24615.1
PFAM: nitrite and sulphite reductase 4Fe-4S region; 4Fe-4S ferredoxin iron-sulfur binding domain protein; nitrite/sulfite reductase hemoprotein beta-component ferrodoxin domain protein; KEGG: gur:Gura_3941 nitrite and sulphite reductase 4Fe-4S region.
   
 0.921
ACV24472.1
Contains selenocysteine; TIGRFAM: formate dehydrogenase, alpha subunit; PFAM: molybdopterin oxidoreductase; molybdopterin oxidoreductase Fe4S4 region; molydopterin dinucleotide-binding region; KEGG: ppd:Ppro_3520 formate dehydrogenase, alpha subunit.
    
 0.916
ACV24865.1
PFAM: beta-lactamase domain protein; flavodoxin/nitric oxide synthase; KEGG: dal:Dalk_2373 beta-lactamase domain protein.
    
 0.839
ACV24383.1
PFAM: beta-lactamase domain protein; KEGG: hypothetical protein.
   
 0.758
ACV25269.1
PFAM: beta-lactamase domain protein; KEGG: sfu:Sfum_1958 beta-lactamase domain protein.
   
 0.758
rps5
Ribosomal protein S5; With S4 and S12 plays an important role in translational accuracy.
  
 
 0.752
ACV24084.1
PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; KEGG: ftn:FTN_1526 dihydrolipoamide dehydrogenase.
 
 
 0.750
rtcA
RNA 3'-phosphate cyclase; Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing.
 
   
 0.676
nadK
ATP-NAD/AcoX kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
  
  
 0.633
Your Current Organism:
Methanocaldococcus fervens
NCBI taxonomy Id: 573064
Other names: M. fervens AG86, Methanocaldococcus fervens AG86, Methanocaldococcus fervens DSM 4213, Methanocaldococcus fervens str. AG86, Methanocaldococcus fervens strain AG86
Server load: low (16%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.