Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
ACV24394.1PFAM: TrkA-N domain protein; Ion transport 2 domain protein; TrkA-C domain protein; KEGG: gem:GM21_3877 TrkA-N domain protein. (332 aa)    
Predicted Functional Partners:
ACV23885.1
PFAM: sodium/hydrogen exchanger; KEGG: fph:Fphi_1574 monovalent cation:proton antiporter family protein.
  
  
 0.952
ACV23861.1
PFAM: TrkA-N domain protein; TrkA-C domain protein; KEGG: lip:LI0774 potassium transporter peripheral membrane component.
  
  
 0.912
ACV24194.1
PFAM: Ion transport 2 domain protein; Ion transport protein; KEGG: similar to predicted protein.
 
   
 0.897
secF
SecD/SecF/SecDF export membrane protein; Involved in protein export.
  
    0.771
secD
SecD/SecF/SecDF export membrane protein; Involved in protein export.
     
 0.750
ACV24193.1
PFAM: Cobyrinic acid ac-diamide synthase; CobB/CobQ domain protein glutamine amidotransferase; KEGG: gur:Gura_0041 cobyric acid synthase CobQ.
  
    0.675
guaAB
GMP synthase, large subunit; Catalyzes the synthesis of GMP from XMP.
     
 0.610
rpl21e
PFAM: Ribosomal protein L21e; KEGG: 60S ribosomal protein L21; K02889 large subunit ribosomal protein L21e; Belongs to the eukaryotic ribosomal protein eL21 family.
       0.542
pus10
THUMP domain protein; Responsible for synthesis of pseudouridine from uracil-54 and uracil-55 in the psi GC loop of transfer RNAs.
       0.542
argD
KEGG: geo:Geob_1122 acetylornithine and succinylornithine aminotransferase; TIGRFAM: acetylornithine and succinylornithine aminotransferase; PFAM: aminotransferase class-III; aminotransferase class I and II; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily.
     
 0.518
Your Current Organism:
Methanocaldococcus fervens
NCBI taxonomy Id: 573064
Other names: M. fervens AG86, Methanocaldococcus fervens AG86, Methanocaldococcus fervens DSM 4213, Methanocaldococcus fervens str. AG86, Methanocaldococcus fervens strain AG86
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