Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
ACV24415.1PFAM: TatD-related deoxyribonuclease; KEGG: mxa:MXAN_1382 TatD family hydrolase. (256 aa)    
Predicted Functional Partners:
ACV24414.1
TIGRFAM: SagB-type dehydrogenase domain; PFAM: nitroreductase; KEGG: sfu:Sfum_0229 nitroreductase.
       0.927
ACV24413.1
Protein of unknown function DUF127; Specifically catalyzes the AdoMet-dependent 2'-O-ribose methylation of cytidine at position 56 in tRNAs; Belongs to the aTrm56 family.
       0.852
ACV24412.1
PFAM: protein of unknown function DUF111; KEGG: sat:SYN_00476 hypothetical protein; Belongs to the LarC family.
       0.551
ACV24464.1
UbiA prenyltransferase; Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C2 hydroxyl of (S)-3-O-geranylgeranylglyceryl phosphate (GGGP). This reaction is the second ether-bond-formation step in the biosynthesis of archaeal membrane lipids.
 
   
 0.495
ACV24410.1
PFAM: protein of unknown function DUF190; KEGG: gem:GM21_0715 protein of unknown function DUF190.
       0.443
ACV24411.1
PFAM: Oligosaccharyl transferase STT3 subunit; KEGG: nam:NAMH_1652 oligosaccharyl transferase, STT3 subunit.
       0.443
ACV24408.1
TIGRFAM: precorrin-6y C5,15-methyltransferase (decarboxylating), CbiE subunit; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; KEGG: dde:Dde_0803 precorrin-6Y C5,15-methyltransferase (decarboxylating).
       0.436
crcB
CrcB protein; Important for reducing fluoride concentration in the cell, thus reducing its toxicity; Belongs to the CrcB (TC 9.B.71) family.
       0.436
Your Current Organism:
Methanocaldococcus fervens
NCBI taxonomy Id: 573064
Other names: M. fervens AG86, Methanocaldococcus fervens AG86, Methanocaldococcus fervens DSM 4213, Methanocaldococcus fervens str. AG86, Methanocaldococcus fervens strain AG86
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