Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
ACV24426.1PFAM: sodium/hydrogen exchanger; KEGG: cja:CJA_2911 putative pH regulated Na(+)/H(+) antiporter. (425 aa)    
Predicted Functional Partners:
ribK
CTP-dependent riboflavin kinase; Catalyzes the CTP-dependent phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN); Belongs to the archaeal riboflavin kinase family.
       0.914
ribB
3,4-dihydroxy-2-butanone 4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.
     
 0.774
ACV24427.1
TIGRFAM: ammonium transporter; PFAM: ammonium transporter; KEGG: gem:GM21_1136 Rh family protein/ammonium transporter.
 
  
 0.703
ACV23885.1
PFAM: sodium/hydrogen exchanger; KEGG: fph:Fphi_1574 monovalent cation:proton antiporter family protein.
   
 
 0.667
ACV23901.1
PFAM: metallophosphoesterase; KEGG: scl:sce7256 putative protein phosphatase.
   
 
 0.644
ACV24185.1
TIGRFAM: DNA helicase; SMART: DEAD-like helicase; KEGG: nam:NAMH_1081 putative DNA helicase.
   
 
 0.644
ACV24401.1
KEGG: afr:AFE_0818 plasma-membrane proton-efflux P-type ATPase; TIGRFAM: plasma-membrane proton-efflux P-type ATPase; ATPase, P-type (transporting), HAD superfamily, subfamily IC; PFAM: E1-E2 ATPase-associated domain protein; Haloacid dehalogenase domain protein hydrolase; cation transporting ATPase domain protein; Haloacid dehalogenase domain protein hydrolase type 3.
   
 
 0.627
ACV25046.1
TIGRFAM: ATPase, P-type (transporting), HAD superfamily, subfamily IC; PFAM: E1-E2 ATPase-associated domain protein; cation transporting ATPase domain protein; Haloacid dehalogenase domain protein hydrolase; KEGG: sat:SYN_01009 calcium-transporting ATPase.
   
 
 0.627
ACV24225.1
TIGRFAM: Na+/Ca+ antiporter, CaCA family; PFAM: sodium/calcium exchanger membrane region; KEGG: pmu:PM0428 hypothetical protein.
 
 
 
 0.619
ACV24423.1
TIGRFAM: methanogenesis marker protein 8; PFAM: conserved hypothetical protein.
       0.599
Your Current Organism:
Methanocaldococcus fervens
NCBI taxonomy Id: 573064
Other names: M. fervens AG86, Methanocaldococcus fervens AG86, Methanocaldococcus fervens DSM 4213, Methanocaldococcus fervens str. AG86, Methanocaldococcus fervens strain AG86
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