Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
ACV24465.1PFAM: domain of unknown function DUF1745; KEGG: sat:SYN_01291 signal transduction histidine kinase. (487 aa)    
Predicted Functional Partners:
ACV24466.1
PFAM: response regulator receiver; SMART: response regulator receiver; KEGG: dvl:Dvul_1155 response regulator receiver protein.
  
  
 0.857
ACV24467.1
Integral membrane sensor signal transduction histidine kinase; PFAM: ATP-binding region ATPase domain protein; histidine kinase HAMP region domain protein; histidine kinase A domain protein; SMART: ATP-binding region ATPase domain protein; histidine kinase A domain protein; histidine kinase HAMP region domain protein; KEGG: geo:Geob_1632 histidine kinase.
 
  
 0.727
ACV24586.1
PFAM: FeoA family protein; KEGG: dat:HRM2_10920 Fur.
  
  
 0.662
ACV24585.1
TIGRFAM: ferrous iron transport protein B; small GTP-binding protein; PFAM: Ferrous iron transport protein B domain protein; GTP-binding protein HSR1-related; nucleoside recognition domain protein; Ferrous iron transport B domain protein; KEGG: gem:GM21_3765 ferrous iron transport protein B.
  
  
 0.653
ACV24919.1
PFAM: CheC domain protein; KEGG: gem:GM21_0635 CheC, inhibitor of MCP methylation.
  
     0.653
ACV24849.1
Transcriptional regulator, MarR family; PFAM: regulatory protein ArsR; regulatory protein MarR; SMART: regulatory protein ArsR; KEGG: ank:AnaeK_0686 general secretion pathway protein-related protein.
 
  
 0.641
ACV25044.1
PFAM: ABC transporter related; SMC domain protein; SMART: AAA ATPase; KEGG: ftm:FTM_0976 SufS activator complex, SufC subunit.
     
 0.629
ACV24464.1
UbiA prenyltransferase; Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C2 hydroxyl of (S)-3-O-geranylgeranylglyceryl phosphate (GGGP). This reaction is the second ether-bond-formation step in the biosynthesis of archaeal membrane lipids.
       0.618
ACV23920.1
Phytoene dehydrogenase and related protein-like protein; KEGG: hypothetical protein.
 
   
 0.592
nac
alpha-NAC related protein; Contacts the emerging nascent chain on the ribosome. Belongs to the NAC-alpha family.
       0.543
Your Current Organism:
Methanocaldococcus fervens
NCBI taxonomy Id: 573064
Other names: M. fervens AG86, Methanocaldococcus fervens AG86, Methanocaldococcus fervens DSM 4213, Methanocaldococcus fervens str. AG86, Methanocaldococcus fervens strain AG86
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