Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
ACV24489.1PFAM: protein of unknown function DUF88; KEGG: pna:Pnap_4909 hypothetical protein. (195 aa)    
Predicted Functional Partners:
tgtA
Archaeosine tRNA-ribosyltransferase; Exchanges the guanine residue with 7-cyano-7-deazaguanine (preQ0) at position 15 in the dihydrouridine loop (D-loop) of archaeal tRNAs; Belongs to the archaeosine tRNA-ribosyltransferase family.
   
   0.725
ACV24225.1
TIGRFAM: Na+/Ca+ antiporter, CaCA family; PFAM: sodium/calcium exchanger membrane region; KEGG: pmu:PM0428 hypothetical protein.
       0.609
ACV24364.1
PFAM: N-6 DNA methylase; restriction modification system DNA specificity domain; KEGG: wsu:WS1649 DNA methylase-type I restriction-modification system.
       0.604
ACV24488.1
Hypothetical protein; KEGG: GJ17740 gene product from transcript GJ17740-RA.
       0.546
purO
IMP cyclohydrolase; Catalyzes the cyclization of 5-formylamidoimidazole-4- carboxamide ribonucleotide to IMP.
  
     0.524
ACV24909.1
PFAM: phosphoesterase RecJ domain protein; RNA binding S1 domain protein; nucleic acid binding OB-fold tRNA/helicase-type; KEGG: dat:HRM2_01850 RecJ-like exonuclease (DnaJ-type Zn finger protein).
 
    0.523
ACV24129.1
PFAM: TatD-related deoxyribonuclease.
 
     0.468
ACV24575.1
TIGRFAM: hydrolase, TatD family; PFAM: TatD-related deoxyribonuclease; KEGG: gur:Gura_2510 TatD family hydrolase.
 
     0.447
ACV24391.1
PFAM: RNA polymerase Rpb4.
  
     0.445
ACV25337.1
PFAM: PilT protein domain protein; KH type 2 domain protein; K Homology, type 1, subgroup; SMART: Nucleotide binding protein PINc; KH domain protein; KEGG: vsp:VS_II0474 putative Flp pilus assembly protein TadA.
  
     0.434
Your Current Organism:
Methanocaldococcus fervens
NCBI taxonomy Id: 573064
Other names: M. fervens AG86, Methanocaldococcus fervens AG86, Methanocaldococcus fervens DSM 4213, Methanocaldococcus fervens str. AG86, Methanocaldococcus fervens strain AG86
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