Nodes:
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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co-expression
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[Homology]
Score
ACV24528.1TIGRFAM: isopropylmalate/citramalate/homocitrate synthase; PFAM: pyruvate carboxyltransferase; KEGG: dde:Dde_3218 2-isopropylmalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. (400 aa)    
Predicted Functional Partners:
ACV24775.1
KEGG: asa:ASA_3183 isocitrate dehydrogenase; TIGRFAM: isopropylmalate/isohomocitrate dehydrogenase; PFAM: isocitrate/isopropylmalate dehydrogenase.
 
 0.975
leuC-2
3-isopropylmalate dehydratase; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate.
 
 
 0.971
hacB
3-isopropylmalate dehydratase, small subunit; Hydro-lyase with broad substrate specificity for cis- unsaturated tricarboxylic acids. Catalyzes both the reversible dehydration of (R)-homocitrate ((R)-2-hydroxybutane-1,2,4- tricarboxylate) to produce cis-homoaconitate ((Z)-but-1-ene-1,2,4- tricarboxylate), and its hydration to homoisocitrate ((1R,2S)-1- hydroxybutane-1,2,4-tricarboxylate). Is also able to hydrate the analogous longer chain substrates cis-homo(2)-aconitate, cis-homo(3)- aconitate. All these reactions are part of the biosynthesis pathway of coenzyme B; Belongs to the LeuD [...]
  
 
 0.965
ACV25286.1
PFAM: Thiolase; KEGG: gur:Gura_4354 thiolase.
  
 
 0.940
ACV23981.1
PFAM: pyruvate flavodoxin/ferredoxin oxidoreductase domain protein; KEGG: dal:Dalk_1629 2-oxoglutarate ferredoxin oxidoreductase subunit alpha.
  
 
 0.930
ACV24148.1
TIGRFAM: acetate/CoA ligase; PFAM: AMP-dependent synthetase and ligase; KEGG: sfu:Sfum_3454 acetate--CoA ligase.
  
 
 0.925
ACV24702.1
PFAM: pyruvate flavodoxin/ferredoxin oxidoreductase domain protein; KEGG: sfu:Sfum_2794 pyruvate flavodoxin/ferredoxin oxidoreductase domain protein.
  
 
 0.914
ACV24601.1
PFAM: thiamine pyrophosphate protein domain protein TPP-binding; KEGG: sfu:Sfum_3139 thiamine pyrophosphate enzyme domain protein TPP-binding.
  
 
 0.913
ACV24701.1
PFAM: thiamine pyrophosphate protein domain protein TPP-binding; KEGG: sat:SYN_00154 pyruvate:ferredoxin oxidoreductase beta subunit.
  
 
 0.913
ACV24704.1
TIGRFAM: pyruvate/ketoisovalerate oxidoreductase, gamma subunit; PFAM: Pyruvate/ketoisovalerate oxidoreductase; KEGG: sat:SYN_00157 pyruvate:ferredoxin oxidoreductase gamma subunit.
  
 
 0.910
Your Current Organism:
Methanocaldococcus fervens
NCBI taxonomy Id: 573064
Other names: M. fervens AG86, Methanocaldococcus fervens AG86, Methanocaldococcus fervens DSM 4213, Methanocaldococcus fervens str. AG86, Methanocaldococcus fervens strain AG86
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