Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
ACV24586.1PFAM: FeoA family protein; KEGG: dat:HRM2_10920 Fur. (76 aa)    
Predicted Functional Partners:
ACV24585.1
TIGRFAM: ferrous iron transport protein B; small GTP-binding protein; PFAM: Ferrous iron transport protein B domain protein; GTP-binding protein HSR1-related; nucleoside recognition domain protein; Ferrous iron transport B domain protein; KEGG: gem:GM21_3765 ferrous iron transport protein B.
 
  
 0.996
ACV24584.1
Hypothetical protein.
       0.865
ACV24587.1
Iron (metal) dependent repressor, DtxR family; PFAM: iron dependent repressor; regulatory protein MarR; SMART: iron dependent repressor; KEGG: dal:Dalk_2732 iron (metal) dependent repressor, DtxR family.
  
  
 0.688
ACV24465.1
PFAM: domain of unknown function DUF1745; KEGG: sat:SYN_01291 signal transduction histidine kinase.
  
  
 0.662
ACV25332.1
PFAM: protein of unknown function UPF0132; KEGG: hha:Hhal_1506 hypothetical protein.
     
 0.629
ACV24457.1
PFAM: Queuosine synthesis-like; KEGG: bba:Bd2064 hypothetical protein.
     
 0.621
nth
DNA-(apurinic or apyrimidinic site) lyase; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate.
     
 0.421
ACV25044.1
PFAM: ABC transporter related; SMC domain protein; SMART: AAA ATPase; KEGG: ftm:FTM_0976 SufS activator complex, SufC subunit.
 
   
 0.408
ACV25067.1
PFAM: zinc/iron permease; KEGG: transmembrane protein.
 
   
 0.405
Your Current Organism:
Methanocaldococcus fervens
NCBI taxonomy Id: 573064
Other names: M. fervens AG86, Methanocaldococcus fervens AG86, Methanocaldococcus fervens DSM 4213, Methanocaldococcus fervens str. AG86, Methanocaldococcus fervens strain AG86
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