Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
ACV24602.1KEGG: hypothetical protein. (258 aa)    
Predicted Functional Partners:
ACV24983.1
PFAM: Radical SAM domain protein; KEGG: sat:SYN_01240 pyruvate formate-lyase activating enzyme.
       0.609
thiL
Thiamine-monophosphate kinase; Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1; Belongs to the thiamine-monophosphate kinase family.
       0.609
ACV24601.1
PFAM: thiamine pyrophosphate protein domain protein TPP-binding; KEGG: sfu:Sfum_3139 thiamine pyrophosphate enzyme domain protein TPP-binding.
       0.599
ACV24250.1
PFAM: PHP domain protein; KEGG: gur:Gura_2545 hypothetical protein.
       0.587
ACV24774.1
PFAM: conserved hypothetical protein; KEGG: geo:Geob_3377 hypothetical protein.
       0.581
lysS
lysyl-tRNA synthetase; KEGG: noc:Noc_1618 lysine--tRNA ligase; TIGRFAM: lysyl-tRNA synthetase; PFAM: Lysyl-tRNA synthetase class 1c; Belongs to the class-I aminoacyl-tRNA synthetase family.
       0.516
ACV25143.1
PFAM: Cl- channel voltage-gated family protein; KEGG: dat:HRM2_22170 EriC2.
       0.482
ACV24600.1
TIGRFAM: pyruvate/ketoisovalerate oxidoreductase, gamma subunit; PFAM: Pyruvate/ketoisovalerate oxidoreductase; KEGG: gur:Gura_2189 pyruvate ferredoxin/flavodoxin oxidoreductase.
       0.427
Your Current Organism:
Methanocaldococcus fervens
NCBI taxonomy Id: 573064
Other names: M. fervens AG86, Methanocaldococcus fervens AG86, Methanocaldococcus fervens DSM 4213, Methanocaldococcus fervens str. AG86, Methanocaldococcus fervens strain AG86
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