Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
ACV24670.1PFAM: phosphoadenosine phosphosulfate reductase; KEGG: gem:GM21_0790 phosphoadenosine phosphosulfate reductase. (409 aa)    
Predicted Functional Partners:
ACV24667.1
TIGRFAM: uroporphyrin-III C-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; KEGG: dal:Dalk_4009 uroporphyrin-III C-methyltransferase; Belongs to the precorrin methyltransferase family.
 
  
 0.746
ACV23858.1
PFAM: binding-protein-dependent transport systems inner membrane component; KEGG: pca:Pcar_2086 ABC-type sulfate transport system, permease component.
 
  
 0.666
ACV24669.1
PFAM: phosphoesterase RecJ domain protein; phosphoesterase DHHA1; KEGG: rak:A1C_03765 single-stranded-DNA-specific exonuclease RecJ.
     
 0.641
hcp
Hybrid cluster protein; Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O.
  
  
 0.631
ACV24968.1
TIGRFAM: NifC-like ABC-type porter; PFAM: binding-protein-dependent transport systems inner membrane component; KEGG: dat:HRM2_01690 putative molybdenum ABC-type transporter, permease subunit.
  
  
 0.611
cbiX
Cobalamin (vitamin B12) biosynthesis CbiX protein; Catalyzes the insertion of Co(2+) into sirohydrochlorin as part of the anaerobic pathway to cobalamin biosynthesis. Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl-coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes the insertion of Ni(2+) into sirohydrochlorin to yield Ni- sirohydrochlorin.
  
  
 0.481
ACV24796.1
TIGRFAM: siroheme synthase; PFAM: TrkA-N domain protein; KEGG: tdn:Suden_1977 siroheme synthase CysG.
  
  
 0.476
ACV24046.1
Transcriptional regulator, XRE family; SMART: helix-turn-helix domain protein.
  
     0.466
ACV25326.1
KEGG: gur:Gura_0039 precorrin-4 C11-methyltransferase; TIGRFAM: precorrin-4 C11-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; Belongs to the precorrin methyltransferase family.
 
   
 0.404
Your Current Organism:
Methanocaldococcus fervens
NCBI taxonomy Id: 573064
Other names: M. fervens AG86, Methanocaldococcus fervens AG86, Methanocaldococcus fervens DSM 4213, Methanocaldococcus fervens str. AG86, Methanocaldococcus fervens strain AG86
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