Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
ACV24685.1PFAM: TPR repeat-containing protein; Tetratricopeptide TPR_2 repeat protein; SMART: Tetratricopeptide repeat; KEGG: TPR Domain containing protein. (318 aa)    
Predicted Functional Partners:
ACV24886.1
PFAM: molybdopterin biosynthesis MoaE protein; KEGG: pin:Ping_2167 molybdopterin biosynthesis MoaE.
  
    0.805
ACV24909.1
PFAM: phosphoesterase RecJ domain protein; RNA binding S1 domain protein; nucleic acid binding OB-fold tRNA/helicase-type; KEGG: dat:HRM2_01850 RecJ-like exonuclease (DnaJ-type Zn finger protein).
  
 0.752
rpoH
RNA polymerase Rpb5; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal RpoH/eukaryotic RPB5 RNA polymerase subunit family.
  
 0.737
alaS
alanyl-tRNA synthetase; Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
   
 0.733
ACV24312.1
PFAM: RNA polymerase insert; RNA polymerase dimerization; SMART: RNA polymerase RpoA/D/Rpb3-type; KEGG: DNA-directed RNA polymerases I and III 40 kDa polypeptide; K03027 DNA-directed RNA Polymerase III subunit C5.
  
 0.731
ACV25200.1
PFAM: Tetratricopeptide TPR_2 repeat protein; TPR repeat-containing protein; SMART: Tetratricopeptide repeat; KEGG: hypothetical protein.
  
     0.714
rpoP
RNA polymerase Rbp10; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal RpoP/eukaryotic RPC10 RNA polymerase subunit family.
  
 0.695
ACV24308.1
PFAM: RNA polymerase, N/8 Kd subunit; KEGG: hypothetical protein; K03007 DNA-directed RNA Polymerase II subunit L.
    
 0.678
ACV25340.1
TIGRFAM: thioredoxin reductase; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; KEGG: nam:NAMH_1523 thioredoxin-disulfide reductase.
  
    0.677
ACV24570.1
KEGG: gur:Gura_2842 AAA family ATPase, CDC48 subfamily protein; TIGRFAM: AAA family ATPase, CDC48 subfamily; PFAM: AAA ATPase central domain protein; cell division protein 48 CDC48 domain 2; Vps4 oligomerisation domain protein; ATPase associated with various cellular activities AAA_5; AAA ATPase VAT domain protein; SMART: AAA ATPase.
  
 
 0.662
Your Current Organism:
Methanocaldococcus fervens
NCBI taxonomy Id: 573064
Other names: M. fervens AG86, Methanocaldococcus fervens AG86, Methanocaldococcus fervens DSM 4213, Methanocaldococcus fervens str. AG86, Methanocaldococcus fervens strain AG86
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