Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
ACV24706.1PFAM: Protein of unknown function DUF357. (97 aa)    
Predicted Functional Partners:
ACV24705.1
Hypothetical protein.
       0.773
dphB
Diphthine synthase; S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis.
 
     0.656
ACV24707.1
PFAM: aminotransferase class I and II; KEGG: sfu:Sfum_0054 aminotransferase, class I and II.
       0.614
ACV24241.1
PFAM: Protein of unknown function DUF555; Belongs to the UPF0212 family.
       0.609
ACV25340.1
TIGRFAM: thioredoxin reductase; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; KEGG: nam:NAMH_1523 thioredoxin-disulfide reductase.
       0.595
pyrG
CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
       0.589
ACV24704.1
TIGRFAM: pyruvate/ketoisovalerate oxidoreductase, gamma subunit; PFAM: Pyruvate/ketoisovalerate oxidoreductase; KEGG: sat:SYN_00157 pyruvate:ferredoxin oxidoreductase gamma subunit.
       0.589
ACV24451.1
PFAM: PUA domain containing protein; SMART: PUA domain containing protein.
  
     0.581
ACV24703.1
TIGRFAM: pyruvate ferredoxin/flavodoxin oxidoreductase, delta subunit; PFAM: 4Fe-4S ferredoxin iron-sulfur binding domain protein; KEGG: sat:SYN_00156 pyruvate:ferredoxin oxidoreductase delta subunit.
       0.569
ACV25131.1
PFAM: Protein of unknown function UPF0179; Belongs to the UPF0179 family.
 
     0.562
Your Current Organism:
Methanocaldococcus fervens
NCBI taxonomy Id: 573064
Other names: M. fervens AG86, Methanocaldococcus fervens AG86, Methanocaldococcus fervens DSM 4213, Methanocaldococcus fervens str. AG86, Methanocaldococcus fervens strain AG86
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