Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
ACV24714.1PFAM: DNA methylase N-4/N-6 domain protein; KEGG: rpi:Rpic_2136 DNA methylase N-4/N-6 domain protein. (292 aa)    
Predicted Functional Partners:
ACV24713.1
PFAM: peptidase dimerization domain protein; peptidase M20; KEGG: bap:BUAP5A_046 acetylornithine deacetylase.
 
     0.816
ACV24711.1
PFAM: protein of unknown function DUF114; KEGG: bbt:BBta_7800 hypothetical protein.
  
    0.792
ACV24712.1
PFAM: protein of unknown function DUF192; KEGG: gem:GM21_3209 protein of unknown function DUF192.
       0.789
ACV24364.1
PFAM: N-6 DNA methylase; restriction modification system DNA specificity domain; KEGG: wsu:WS1649 DNA methylase-type I restriction-modification system.
   
 
 0.752
sucC
succinyl-CoA synthetase, beta subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
  
  
 0.604
sucD
succinyl-CoA synthetase, alpha subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.
  
    0.596
ACV24710.1
PFAM: AAA ATPase central domain protein; ATPase associated with various cellular activities AAA_5; SMART: AAA ATPase; KEGG: hypothetical protein.
       0.560
ACV24195.1
PFAM: CBS domain containing protein; ParB domain protein nuclease; SMART: ParB domain protein nuclease; CBS domain containing protein; KEGG: similar to inosine-5-monophosphate dehydrogenase; K00088 IMP dehydrogenase.
  
  
 0.467
ACV25345.1
Hypothetical protein.
  
    0.425
Your Current Organism:
Methanocaldococcus fervens
NCBI taxonomy Id: 573064
Other names: M. fervens AG86, Methanocaldococcus fervens AG86, Methanocaldococcus fervens DSM 4213, Methanocaldococcus fervens str. AG86, Methanocaldococcus fervens strain AG86
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