Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
ACV24735.1PFAM: protein of unknown function DUF107; KEGG: hch:HCH_01497 membrane-bound serine protease (ClpP class). (138 aa)    
Predicted Functional Partners:
ACV24736.1
PFAM: band 7 protein; SMART: band 7 protein; KEGG: sat:SYN_02180 membrane protease subunit, stomatin/prohibitin -like protein.
 
 
 0.993
cobS
Cobalamin 5'-phosphate synthase; Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'- phosphate; Belongs to the CobS family.
  
    0.827
prf1
eRF1 domain 2 protein; Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA.
 
     0.611
ACV24734.1
PFAM: peptidylprolyl isomerase FKBP-type; KEGG: nis:NIS_1212 FKBP-type peptidyl-prolyl cis-trans isomerase SlyD.
       0.530
ACV24987.1
TIGRFAM: precorrin-3B C17-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; KEGG: stm:STM2027 precorrin-3B C17-methyltransferase.
  
    0.505
ACV24180.1
KEGG: nis:NIS_1773 pyruvate kinase; TIGRFAM: pyruvate kinase; PFAM: Pyruvate kinase barrel; Pyruvate kinase alpha/beta; Belongs to the pyruvate kinase family.
 
   
 0.500
ACV24616.1
TIGRFAM: precorrin-6x reductase; PFAM: Precorrin-6x reductase CbiJ/CobK; KEGG: cvi:CV_1562 precorrin-3B C17-methyltransferase.
  
    0.467
ACV23864.1
PFAM: 4Fe-4S ferredoxin iron-sulfur binding domain protein; KEGG: esa:ESA_01916 hypothetical protein.
  
   
 0.448
ACV24193.1
PFAM: Cobyrinic acid ac-diamide synthase; CobB/CobQ domain protein glutamine amidotransferase; KEGG: gur:Gura_0041 cobyric acid synthase CobQ.
  
    0.422
cobQ
Cobyric acid synthase CobQ; Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily.
  
    0.422
Your Current Organism:
Methanocaldococcus fervens
NCBI taxonomy Id: 573064
Other names: M. fervens AG86, Methanocaldococcus fervens AG86, Methanocaldococcus fervens DSM 4213, Methanocaldococcus fervens str. AG86, Methanocaldococcus fervens strain AG86
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