Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
ACV24771.1PFAM: phosphoesterase PA-phosphatase related; SMART: phosphoesterase PA-phosphatase related; KEGG: nis:NIS_1417 PAP2 family phosphoesterase. (244 aa)    
Predicted Functional Partners:
ACV24770.1
PFAM: protein of unknown function UPF0153; KEGG: hac:Hac_0532 hypothetical protein.
  
    0.856
atpC
ATP synthase A1, C subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane.
   
 
 0.739
rpl6
Ribosomal protein L6P; This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center; Belongs to the universal ribosomal protein uL6 family.
   
 0.715
ACV24284.1
PFAM: V-type ATPase 116 kDa subunit; KEGG: gur:Gura_0418 H(+)-transporting two-sector ATPase.
   
 
 0.692
atpF
Vacuolar H+transporting two-sector ATPase F subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane.
  
 
 0.655
ACV24238.1
KEGG: nam:NAMH_1388 HAD fAmily hydrolase fragment.
       0.609
ACV24772.1
PFAM: thiamine pyrophosphate protein domain protein TPP-binding; thiamine pyrophosphate protein TPP binding domain protein; KEGG: abu:Abu_1156 acetolactate synthase 3 catalytic subunit; Belongs to the TPP enzyme family.
  
  
 0.575
ACV24769.1
PFAM: deoxyribonuclease/rho motif-related TRAM; KEGG: dol:Dole_1585 RNA methyltransferase.
       0.527
ACV24626.1
Transcription termination factor Tfs; KEGG: RPC11; DNA-directed RNA polymerase III; TIGRFAM: transcription factor S; PFAM: DNA-directed RNA polymerase, M/15 kDa subunit; Transcription factor TFIIS; SMART: Transcription factor TFIIS; DNA-directed RNA polymerase, M/15 kDa subunit; Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.
   
 0.482
Your Current Organism:
Methanocaldococcus fervens
NCBI taxonomy Id: 573064
Other names: M. fervens AG86, Methanocaldococcus fervens AG86, Methanocaldococcus fervens DSM 4213, Methanocaldococcus fervens str. AG86, Methanocaldococcus fervens strain AG86
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