Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
ACV24773.1PFAM: DNA topoisomerase type IA zn finger domain protein; KEGG: hso:HS_1737 DNA topoisomerase III. (290 aa)    
Predicted Functional Partners:
ACV24772.1
PFAM: thiamine pyrophosphate protein domain protein TPP-binding; thiamine pyrophosphate protein TPP binding domain protein; KEGG: abu:Abu_1156 acetolactate synthase 3 catalytic subunit; Belongs to the TPP enzyme family.
  
  
 0.906
ACV23944.1
PFAM: (2R)-phospho-3-sulfolactate synthase ComA; KEGG: phosphosulfolactate synthase.
  
    0.820
leuS
TIGRFAM: leucyl-tRNA synthetase; KEGG: similar to CG33123-PA; K01869 leucyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family.
   
 
 0.812
ACV24312.1
PFAM: RNA polymerase insert; RNA polymerase dimerization; SMART: RNA polymerase RpoA/D/Rpb3-type; KEGG: DNA-directed RNA polymerases I and III 40 kDa polypeptide; K03027 DNA-directed RNA Polymerase III subunit C5.
   
 
 0.748
ACV23942.1
PFAM: thiamine pyrophosphate protein domain protein TPP-binding; KEGG: sdn:Sden_1162 thiamine pyrophosphate enzyme-like TPP-binding.
  
    0.699
ACV23943.1
KEGG: scl:sce7306 hypothetical protein.
  
    0.699
ACV25071.1
PFAM: RNA polymerase beta subunit; RNA polymerase Rpb2 domain 2; RNA polymerase Rpb2 domain 3; KEGG: hypothetical protein LOC100252267; K03010 DNA-directed RNA polymerase II subunit B.
   
 
 0.669
ACV25072.1
DNA-directed RNA polymerase subunit B; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
   
 
 0.669
ACV24364.1
PFAM: N-6 DNA methylase; restriction modification system DNA specificity domain; KEGG: wsu:WS1649 DNA methylase-type I restriction-modification system.
   
 
 0.656
rps2
TIGRFAM: ribosomal protein S2; PFAM: ribosomal protein S2; KEGG: RSP1; 40S ribosomal protein-like protein; K02998 small subunit ribosomal protein SAe; Belongs to the universal ribosomal protein uS2 family.
  
  
 0.652
Your Current Organism:
Methanocaldococcus fervens
NCBI taxonomy Id: 573064
Other names: M. fervens AG86, Methanocaldococcus fervens AG86, Methanocaldococcus fervens DSM 4213, Methanocaldococcus fervens str. AG86, Methanocaldococcus fervens strain AG86
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