STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
tgtAArchaeosine tRNA-ribosyltransferase; Exchanges the guanine residue with 7-cyano-7-deazaguanine (preQ0) at position 15 in the dihydrouridine loop (D-loop) of archaeal tRNAs; Belongs to the archaeosine tRNA-ribosyltransferase family. (658 aa)    
Predicted Functional Partners:
nac
alpha-NAC related protein; Contacts the emerging nascent chain on the ribosome. Belongs to the NAC-alpha family.
 
     0.940
ACV25230.1
PFAM: phosphate transporter; KEGG: sse:Ssed_0370 phosphate transporter.
  
    0.940
ACV24451.1
PFAM: PUA domain containing protein; SMART: PUA domain containing protein.
 
 
0.931
ACV24884.1
PFAM: ABC transporter related; 4Fe-4S ferredoxin iron-sulfur binding domain protein; metal-binding domain in RNase L inhibitor, RLI; SMART: AAA ATPase; KEGG: similar to ATP-binding cassette, sub-family E, member 1; K06174 ATP-binding cassette, sub-family E, member 1.
  
    0.892
truB
rRNA pseudouridine synthase; Could be responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs; Belongs to the pseudouridine synthase TruB family. Type 2 subfamily.
  
  
 0.891
ACV24799.1
KEGG: gbm:Gbem_1676 hypothetical protein.
 
     0.885
pth
Aminoacyl-tRNA hydrolase; The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.
       0.884
ACV24580.1
PFAM: protein of unknown function DUF752; KEGG: tdn:Suden_1933 hypothetical protein.
     
 0.873
ACV24966.1
PFAM: tRNA methyltransferase complex GCD14 subunit; KEGG: sfu:Sfum_2514 SAM-dependent methyltransferase.
  
  
 0.861
ACV25177.1
Transcriptional regulator, XRE family; PFAM: helix-turn-helix domain protein; SMART: helix-turn-helix domain protein; KEGG: similar to multiprotein bridging factor 1 CG4143-PA, isoform A; K03627 putative transcription factor.
 
     0.861
Your Current Organism:
Methanocaldococcus fervens
NCBI taxonomy Id: 573064
Other names: M. fervens AG86, Methanocaldococcus fervens AG86, Methanocaldococcus fervens DSM 4213, Methanocaldococcus fervens str. AG86, Methanocaldococcus fervens strain AG86
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.