Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
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experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
ACV24800.1PFAM: putative RNA methylase; THUMP domain protein; KEGG: buc:BU363 23S rRNA m(2)G2445 methyltransferase. (381 aa)    
Predicted Functional Partners:
ACV24801.1
PFAM: Protein of unknown function DUF63.
       0.911
tgtA
Archaeosine tRNA-ribosyltransferase; Exchanges the guanine residue with 7-cyano-7-deazaguanine (preQ0) at position 15 in the dihydrouridine loop (D-loop) of archaeal tRNAs; Belongs to the archaeosine tRNA-ribosyltransferase family.
  
  
 0.842
ACV23972.1
PFAM: GTP-binding protein HSR1-related; KEGG: similar to CG3983-PB, isoform B.
 
  
 0.799
thiI
Thiamine biosynthesis/tRNA modification protein ThiI; Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS.
  
  
 0.771
uppS
Undecaprenyl diphosphate synthase; Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with geranylgeranyl diphosphate (GGPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30E,34E,38E)-undecaprenyl diphosphate (tritrans,heptacis-UPP). It is probably the precursor of glycosyl carrier lipids.
 
    0.748
ACV24799.1
KEGG: gbm:Gbem_1676 hypothetical protein.
       0.698
ACV24105.1
PFAM: protein of unknown function Met10; methyltransferase small; PUA domain containing protein; SMART: PUA domain containing protein; KEGG: tau:Tola_2004 PUA domain containing protein.
 
  
 0.622
ACV24743.1
PFAM: Protein of unknown function DUF515; KEGG: IMH1; potential GRIP domain protein similar to S. cerevisiae IMH1 (YLR309C); possible Golgi localization and role in protein transport under stress conditions.
       0.609
ACV24844.1
PFAM: Type II secretion system F domain; KEGG: pag:PLES_46811 TadB.
       0.609
pyrG
CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
  
    0.572
Your Current Organism:
Methanocaldococcus fervens
NCBI taxonomy Id: 573064
Other names: M. fervens AG86, Methanocaldococcus fervens AG86, Methanocaldococcus fervens DSM 4213, Methanocaldococcus fervens str. AG86, Methanocaldococcus fervens strain AG86
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