Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
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experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
ACV24821.1TIGRFAM: methanogenesis marker protein 17; PFAM: Uncharacterized conserved protein UCP019464, methanogenesis. (188 aa)    
Predicted Functional Partners:
ACV24222.1
TIGRFAM: methanogenesis marker protein 7; PFAM: Protein of unknown function UCP019164.
 
 
 
 0.992
ACV24754.1
TIGRFAM: methyl-coenzyme M reductase I operon protein C; PFAM: Methyl-coenzyme M reductase protein C.
 
 
 
 0.970
ACV25125.1
TIGRFAM: methanogenesis marker protein 3; Belongs to the UPF0288 family.
 
   
 0.961
ACV24213.1
KEGG: ara:Arad_7321 peptide ABC transporter; TIGRFAM: methyl coenzyme M reductase system, component A2; PFAM: ABC transporter related; SMART: AAA ATPase.
 
 
 
 0.956
ACV24756.1
Methyl-coenzyme M reductase, alpha subunit; Component of the methyl-coenzyme M reductase (MCR) I that catalyzes the reductive cleavage of methyl-coenzyme M (CoM-S-CH3 or 2- (methylthio)ethanesulfonate) using coenzyme B (CoB or 7- mercaptoheptanoylthreonine phosphate) as reductant which results in the production of methane and the mixed heterodisulfide of CoB and CoM (CoM-S-S-CoB). This is the final step in methanogenesis.
 
 
 
 0.929
ACV24820.1
TIGRFAM: methanogenesis marker protein 15; CoA-substrate-specific enzyme activase; PFAM: ATPase BadF/BadG/BcrA/BcrD type; KEGG: sfu:Sfum_1829 putative CoA-substrate-specific enzyme activase.
 
     0.909
ACV24752.1
TIGRFAM: methyl-coenzyme M reductase, beta subunit; PFAM: Methyl-coenzyme M reductase, beta subunit.
 
 
 
 0.896
ACV24822.1
PFAM: Radical SAM domain protein; KEGG: lpf:lpl0804 hypothetical protein.
       0.870
ACV24755.1
TIGRFAM: methyl-coenzyme M reductase, gamma subunit; PFAM: Methyl-coenzyme M reductase, gamma subunit.
 
 
 
 0.867
ACV24532.1
TIGRFAM: methanogenesis marker protein 6; PFAM: conserved hypothetical protein.
 
     0.843
Your Current Organism:
Methanocaldococcus fervens
NCBI taxonomy Id: 573064
Other names: M. fervens AG86, Methanocaldococcus fervens AG86, Methanocaldococcus fervens DSM 4213, Methanocaldococcus fervens str. AG86, Methanocaldococcus fervens strain AG86
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