Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
ACV24861.1Putative transcriptional regulator, CopG family; PFAM: CopG domain protein DNA-binding domain protein; KEGG: sat:SYN_00477 nickel-responsive regulator. (135 aa)    
Predicted Functional Partners:
ogg
DNA-(apurinic or apyrimidinic site) lyase; Responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine = 7-oxoG) from DNA. Also nicks DNA at apurinic/apyrimidinic sites (AP sites); Belongs to the type-2 OGG1 family.
       0.789
ACV24863.1
TIGRFAM: archaeoflavoprotein AfpA; PFAM: flavoprotein; KEGG: mmb:Mmol_0896 flavoprotein.
 
     0.740
ACV24859.1
KEGG: sat:SYN_00238 putative cytoplasmic protein.
  
  
 0.501
hcp
Hybrid cluster protein; Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O.
       0.485
ACV25231.1
TIGRFAM: hydrogenase maturation protease HycI; hydrogenase maturation protease; PFAM: peptidase M52 hydrogen uptake protein; KEGG: ppd:Ppro_0598 hydrogenase maturation protease.
 
     0.458
hypA
Hydrogenase nickel insertion protein HypA; Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase.
     
 0.443
Your Current Organism:
Methanocaldococcus fervens
NCBI taxonomy Id: 573064
Other names: M. fervens AG86, Methanocaldococcus fervens AG86, Methanocaldococcus fervens DSM 4213, Methanocaldococcus fervens str. AG86, Methanocaldococcus fervens strain AG86
Server load: low (18%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.