Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
ACV24894.1PFAM: protein of unknown function DUF95 transmembrane; KEGG: RNA methyltransferase, TrmH family protein. (214 aa)    
Predicted Functional Partners:
ACV24895.1
TIGRFAM: 3-hydroxy-3-methylglutaryl Coenzyme A reductase; PFAM: hydroxymethylglutaryl-coenzyme A reductase; KEGG: hypothetical protein; K00021 3-hydroxy-3-methylglutaryl-CoA reductase; Belongs to the HMG-CoA reductase family.
       0.981
ACV24801.1
PFAM: Protein of unknown function DUF63.
 
   
 0.900
ACV25131.1
PFAM: Protein of unknown function UPF0179; Belongs to the UPF0179 family.
 
   
 0.866
ACV24896.1
KEGG: hypothetical protein.
  
    0.807
ACV24897.1
Hypothetical protein.
       0.757
egsA
3-dehydroquinate synthase; Catalyzes the NAD(P)H-dependent reduction of dihydroxyacetonephosphate (DHAP or glycerone phosphate) to glycerol 1- phosphate (G1P). The G1P thus generated is used as the glycerophosphate backbone of phospholipids in the cellular membranes of Archaea. Belongs to the glycerol-1-phosphate dehydrogenase family.
  
  
 0.730
ACV23871.1
Transcriptional regulator, MarR family; PFAM: regulatory protein MarR; KEGG: viral A-type inclusion protein.
  
     0.638
ACV25359.1
Hypothetical protein; KEGG: eea-1; EEA1 (Early Endosome Antigen, Rab effector) homolog; K12478 early endosome antigen 1.
  
     0.619
ACV25067.1
PFAM: zinc/iron permease; KEGG: transmembrane protein.
 
    0.617
argS
KEGG: rma:Rmag_0079 arginyl-tRNA synthetase; TIGRFAM: arginyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family.
       0.609
Your Current Organism:
Methanocaldococcus fervens
NCBI taxonomy Id: 573064
Other names: M. fervens AG86, Methanocaldococcus fervens AG86, Methanocaldococcus fervens DSM 4213, Methanocaldococcus fervens str. AG86, Methanocaldococcus fervens strain AG86
Server load: low (16%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.