Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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Neighborhood
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Co-occurrence
Co-expression
Experiments
Databases
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[Homology]
Score
ACV24901.1PFAM: MscS Mechanosensitive ion channel; KEGG: hac:Hac_0544 hypothetical protein. (324 aa)    
Predicted Functional Partners:
polB
DNA-directed DNA polymerase; Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3' to 5' direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase; Belongs to the DNA polymerase delta/II small subunit family.
  
    0.981
priL
DNA primase, large subunit; Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair.
       0.981
ACV24898.1
TIGRFAM: hisA/hisF family protein; PFAM: histidine biosynthesis protein; KEGG: mei:Msip34_1494 histidine biosynthesis protein; Belongs to the HisA/HisF family.
       0.727
ACV24106.1
PFAM: NMD3 family protein.
   
    0.620
ACV24902.1
PFAM: amidohydrolase; KEGG: cbc:CbuK_1316 chlorohydrolase/deaminase family protein.
     
 0.610
ACV24894.1
PFAM: protein of unknown function DUF95 transmembrane; KEGG: RNA methyltransferase, TrmH family protein.
 
     0.546
ACV24580.1
PFAM: protein of unknown function DUF752; KEGG: tdn:Suden_1933 hypothetical protein.
 
   
 0.483
ACV24897.1
Hypothetical protein.
       0.442
ACV24895.1
TIGRFAM: 3-hydroxy-3-methylglutaryl Coenzyme A reductase; PFAM: hydroxymethylglutaryl-coenzyme A reductase; KEGG: hypothetical protein; K00021 3-hydroxy-3-methylglutaryl-CoA reductase; Belongs to the HMG-CoA reductase family.
       0.436
ACV24896.1
KEGG: hypothetical protein.
       0.432
Your Current Organism:
Methanocaldococcus fervens
NCBI taxonomy Id: 573064
Other names: M. fervens AG86, Methanocaldococcus fervens AG86, Methanocaldococcus fervens DSM 4213, Methanocaldococcus fervens str. AG86, Methanocaldococcus fervens strain AG86
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