Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
ACV24920.1PFAM: CheC domain protein; KEGG: gem:GM21_0635 CheC, inhibitor of MCP methylation. (251 aa)    
Predicted Functional Partners:
ACV24919.1
PFAM: CheC domain protein; KEGG: gem:GM21_0635 CheC, inhibitor of MCP methylation.
 
 
 
0.998
cheD
CheD, stimulates methylation of MCP protein; Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis; Belongs to the CheD family.
 
 0.996
ACV24921.1
PFAM: response regulator receiver; SMART: response regulator receiver; KEGG: ank:AnaeK_4453 response regulator receiver protein.
 
 
 0.985
ACV24461.1
PFAM: CheW domain protein; SMART: CheW domain protein; KEGG: dma:DMR_10020 chemotaxis protein CheW.
 
  
 0.906
cheB
Response regulator receiver modulated CheB methylesterase; Involved in chemotaxis. Part of a chemotaxis signal transduction system that modulates chemotaxis in response to various stimuli. Catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins or MCP) by CheR. Also mediates the irreversible deamidation of specific glutamine residues to glutamic acid. Belongs to the CheB family.
 
  
 0.846
ACV24459.1
CheA signal transduction histidine kinase; PFAM: ATP-binding region ATPase domain protein; CheW domain protein; Signal transducing histidine kinase homodimeric; Hpt domain protein; P2 response regulator binding domain protein; SMART: Hpt domain protein; ATP-binding region ATPase domain protein; CheW domain protein; KEGG: nam:NAMH_0362 chemotaxis protein CheA.
 
  
 0.839
ACV24918.1
KEGG: geo:Geob_0927 MCP methyltransferase, CheR-type; PFAM: MCP methyltransferase CheR-type; SMART: MCP methyltransferase CheR-type.
 
  
 0.598
ACV24923.1
PFAM: chemotaxis sensory transducer; SMART: chemotaxis sensory transducer; KEGG: psb:Psyr_2188 histidine kinase, HAMP region: chemotaxis sensory transducer:CHASE3.
 
 
 0.564
ACV24922.1
PFAM: Protein of unknown function DUF439.
     
 0.534
ACV25014.1
PFAM: Type II secretion system F domain.
 
  
 0.534
Your Current Organism:
Methanocaldococcus fervens
NCBI taxonomy Id: 573064
Other names: M. fervens AG86, Methanocaldococcus fervens AG86, Methanocaldococcus fervens DSM 4213, Methanocaldococcus fervens str. AG86, Methanocaldococcus fervens strain AG86
Server load: low (34%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.