Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
ACV24959.1Histone acetyltransferase, ELP3 family; KEGG: hypothetical protein; K07739 elongator complex protein 3; TIGRFAM: histone acetyltransferase, ELP3 family; PFAM: Radical SAM domain protein; GCN5-related N-acetyltransferase; SMART: Elongator protein 3/MiaB/NifB. (536 aa)    
Predicted Functional Partners:
ACV25342.1
TIGRFAM: L-seryl-tRNA(Sec) kinase; PFAM: Chromatin associated protein KTI12; KEGG: hypothetical protein.
  
 
 0.903
ACV23918.1
PFAM: Protein of unknown function UPF0113.
  
    0.760
tuf
Translation elongation factor EF-1, subunit alpha; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
    
   0.757
ACV24106.1
PFAM: NMD3 family protein.
   
  
 0.722
truA
tRNA pseudouridine synthase A; Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs; Belongs to the tRNA pseudouridine synthase TruA family.
   
 
 0.705
ACV24568.1
PFAM: PP-loop domain protein; KEGG: hypothetical protein.
   
 
 0.660
ACV25276.1
PFAM: protein of unknown function Met10; methyltransferase small; KEGG: Met-10+ like family protein.
 
  
 0.646
rtcA
RNA 3'-phosphate cyclase; Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing.
   
  
 0.634
rsmA
Dimethyladenosine transferase; Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits. Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.
  
  
 0.631
rps6e
PFAM: Ribosomal protein S6e; KEGG: 40S ribosomal protein S6; K02991 small subunit ribosomal protein S6e; Belongs to the eukaryotic ribosomal protein eS6 family.
  
   0.616
Your Current Organism:
Methanocaldococcus fervens
NCBI taxonomy Id: 573064
Other names: M. fervens AG86, Methanocaldococcus fervens AG86, Methanocaldococcus fervens DSM 4213, Methanocaldococcus fervens str. AG86, Methanocaldococcus fervens strain AG86
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