Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
ACV24984.1PFAM: AMMECR1 domain protein; KEGG: ppd:Ppro_3512 AMMECR1 domain-containing protein. (199 aa)    
Predicted Functional Partners:
ACV24993.1
PFAM: protein of unknown function DUF52; KEGG: pca:Pcar_1651 dioxygenase; Belongs to the MEMO1 family.
    0.992
ACV24983.1
PFAM: Radical SAM domain protein; KEGG: sat:SYN_01240 pyruvate formate-lyase activating enzyme.
     0.978
ACV23951.1
PFAM: protein of unknown function DUF77; KEGG: sfu:Sfum_0022 protein of unknown function DUF77.
  
    0.629
pyrC
Dihydroorotase, multifunctional complex type; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily.
       0.609
ACV24970.1
PFAM: Xylose isomerase domain protein TIM barrel; SMART: AP endonuclease family 2; KEGG: dma:DMR_37530 putative endonuclease IV.
       0.609
ACV25063.1
PFAM: Protein of unknown function DUF373.
       0.609
pgk
PFAM: phosphoglycerate kinase; KEGG: ade:Adeh_1531 phosphoglycerate kinase; Belongs to the phosphoglycerate kinase family.
       0.605
ACV25181.1
TIGRFAM: acetyl coenzyme A synthetase (ADP forming), alpha domain protein; PFAM: CoA-binding domain protein; KEGG: dal:Dalk_1024 acetyl coenzyme A synthetase (ADP forming), alpha domain protein.
       0.593
ACV25295.1
PFAM: peptidase U62 modulator of DNA gyrase; KEGG: gur:Gura_3701 peptidase U62, modulator of DNA gyrase.
       0.590
ACV24982.1
PFAM: protein of unknown function DUF98; KEGG: sde:Sde_3289 hypothetical protein.
       0.584
Your Current Organism:
Methanocaldococcus fervens
NCBI taxonomy Id: 573064
Other names: M. fervens AG86, Methanocaldococcus fervens AG86, Methanocaldococcus fervens DSM 4213, Methanocaldococcus fervens str. AG86, Methanocaldococcus fervens strain AG86
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