Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
ACV25059.1PFAM: Radical SAM domain protein; KEGG: pca:Pcar_1369 hypothetical protein. (377 aa)    
Predicted Functional Partners:
cbiD
Cobalamin biosynthesis protein CbiD; Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A.
       0.966
ACV25063.1
PFAM: Protein of unknown function DUF373.
 
     0.792
rnp2
Ribonuclease P; Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends; Belongs to the eukaryotic/archaeal RNase P protein component 2 family.
  
    0.644
uppS
Undecaprenyl diphosphate synthase; Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with geranylgeranyl diphosphate (GGPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30E,34E,38E)-undecaprenyl diphosphate (tritrans,heptacis-UPP). It is probably the precursor of glycosyl carrier lipids.
       0.609
lysS
lysyl-tRNA synthetase; KEGG: noc:Noc_1618 lysine--tRNA ligase; TIGRFAM: lysyl-tRNA synthetase; PFAM: Lysyl-tRNA synthetase class 1c; Belongs to the class-I aminoacyl-tRNA synthetase family.
       0.608
ACV25096.1
PFAM: Fibronectin-binding A domain protein; protein of unknown function DUF814; KEGG: hypothetical protein.
       0.593
ACV25284.1
Transcriptional regulator, XRE family; PFAM: helix-turn-helix domain protein; SMART: helix-turn-helix domain protein.
  
     0.593
ACV24672.1
PFAM: peptidase M50; KEGG: geo:Geob_1515 membrane-associated zinc metalloprotease.
 
     0.560
ACV24371.1
PFAM: Protein of unknown function DUF54; KEGG: hypothetical protein; Belongs to the UPF0201 family.
  
     0.540
gatE
aspartyl-tRNA(Asn) amidotransferase, B subunit; Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu- tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate.
 
     0.538
Your Current Organism:
Methanocaldococcus fervens
NCBI taxonomy Id: 573064
Other names: M. fervens AG86, Methanocaldococcus fervens AG86, Methanocaldococcus fervens DSM 4213, Methanocaldococcus fervens str. AG86, Methanocaldococcus fervens strain AG86
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