Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
ACV25098.1PFAM: TOPRIM domain protein; SMART: Toprim sub domain protein; Belongs to the UPF0292 family. (128 aa)    
Predicted Functional Partners:
ACV25097.1
Hypothetical protein; KEGG: similar to viral A-type inclusion protein.
       0.957
ACV24450.1
KEGG: apl:APL_0382 riboflavin biosynthesis protein; TIGRFAM: 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)pyrimidine 1-reductase; PFAM: bifunctional deaminase-reductase domain protein.
      0.781
ACV25096.1
PFAM: Fibronectin-binding A domain protein; protein of unknown function DUF814; KEGG: hypothetical protein.
       0.746
ACV24049.1
PFAM: protein of unknown function DUF167; KEGG: sfu:Sfum_4080 protein of unknown function DUF167; Belongs to the UPF0235 family.
 
     0.733
dnaG
TOPRIM domain protein; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.
 
   
 0.711
rsmA
Dimethyladenosine transferase; Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits. Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.
 
  
 0.700
gltX
glutamyl-tRNA synthetase; Catalyzes the attachment of glutamate to tRNA(Glu) in a two- step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
  
  
 0.652
tmk
KEGG: wpi:WPa_0905 thymidylate kinase; TIGRFAM: thymidylate kinase; PFAM: thymidylate kinase.
 
     0.629
ACV24391.1
PFAM: RNA polymerase Rpb4.
  
     0.623
ACV24282.1
PFAM: Protein of unknown function DUF531.
  
   
 0.575
Your Current Organism:
Methanocaldococcus fervens
NCBI taxonomy Id: 573064
Other names: M. fervens AG86, Methanocaldococcus fervens AG86, Methanocaldococcus fervens DSM 4213, Methanocaldococcus fervens str. AG86, Methanocaldococcus fervens strain AG86
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