Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
ACV25111.1PFAM: PHP domain protein; SMART: phosphoesterase PHP domain protein; KEGG: ank:AnaeK_1370 PHP domain protein. (237 aa)    
Predicted Functional Partners:
ACV24327.1
PFAM: conserved hypothetical protein; KEGG: nis:NIS_1113 hypothetical protein.
 
     0.649
ACV25107.1
PFAM: THUMP domain protein; KEGG: ebw:BWG_0305 sulfurtransferase required for thiamine and 4-thiouridine biosynthesis.
       0.559
ACV25108.1
PFAM: Protein of unknown function DUF70; KEGG: Hypothetical protein CBG09235.
       0.547
ACV25109.1
PFAM: Protein of unknown function DUF70; KEGG: gsu:GSU1852 hypothetical protein.
       0.546
ACV25110.1
Hypothetical protein.
       0.546
ACV24559.1
PFAM: Translin; KEGG: Translin family protein.
  
     0.438
cofC
2-phospho-L-lactate guanylyltransferase CofC; Guanylyltransferase that catalyzes the activation of phosphoenolpyruvate (PEP) as enolpyruvoyl-2-diphospho-5'-guanosine, via the condensation of PEP with GTP. It is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor; Belongs to the CofC family.
 
     0.438
ACV24567.1
PFAM: nucleic acid binding OB-fold tRNA/helicase-type; KEGG: hypothetical protein; K07466 replication factor A1.
 
     0.433
nusA
NusA family KH domain protein; Participates in transcription termination. Belongs to the NusA family.
 
   
 0.420
Your Current Organism:
Methanocaldococcus fervens
NCBI taxonomy Id: 573064
Other names: M. fervens AG86, Methanocaldococcus fervens AG86, Methanocaldococcus fervens DSM 4213, Methanocaldococcus fervens str. AG86, Methanocaldococcus fervens strain AG86
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