Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
ACV25126.1PFAM: Aldehyde Dehydrogenase; KEGG: gur:Gura_1578 aldehyde dehydrogenase. (463 aa)    
Predicted Functional Partners:
ACV25036.1
TIGRFAM: thermosome; PFAM: chaperonin Cpn60/TCP-1; KEGG: cct3; chaperonin subunit 3 (gamma); K09495 T-complex protein 1 subunit gamma.
  
 0.893
ACV24540.1
PFAM: Lactate/malate dehydrogenase; KEGG: ama:AM564 malate dehydrogenase; Belongs to the LDH/MDH superfamily.
  
 0.884
ACV23985.1
TIGRFAM: agmatinase; PFAM: Arginase/agmatinase/formiminoglutamase; KEGG: ilo:IL1212 agmatinase; Belongs to the arginase family.
  
 0.869
ACV25286.1
PFAM: Thiolase; KEGG: gur:Gura_4354 thiolase.
 
 0.844
ACV25125.1
TIGRFAM: methanogenesis marker protein 3; Belongs to the UPF0288 family.
  
    0.793
rps2
TIGRFAM: ribosomal protein S2; PFAM: ribosomal protein S2; KEGG: RSP1; 40S ribosomal protein-like protein; K02998 small subunit ribosomal protein SAe; Belongs to the universal ribosomal protein uS2 family.
  
 0.790
sucC
succinyl-CoA synthetase, beta subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
 
 0.786
ACV23959.1
Peptidase S16, Lon-like protease; KEGG: son:SO_3391 ATP-dependent protease, putative; TIGRFAM: peptidase S16, Lon-like protease; PFAM: peptidase S16 lon domain protein; SMART: AAA ATPase; Belongs to the peptidase S16 family.
    
 0.785
nadK
ATP-NAD/AcoX kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
  
 
 0.780
ACV24138.1
TIGRFAM: asparagine synthase (glutamine-hydrolyzing); PFAM: asparagine synthase; glutamine amidotransferase class-II; KEGG: wbr:WGLp587 asparagine synthetase B.
  
 
 0.770
Your Current Organism:
Methanocaldococcus fervens
NCBI taxonomy Id: 573064
Other names: M. fervens AG86, Methanocaldococcus fervens AG86, Methanocaldococcus fervens DSM 4213, Methanocaldococcus fervens str. AG86, Methanocaldococcus fervens strain AG86
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