Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
ACV25134.1PFAM: TrkA-N domain protein; phosphoesterase DHHA1; phosphoesterase RecJ domain protein; KEGG: dol:Dole_0370 phosphoesterase domain-containing protein. (475 aa)    
Predicted Functional Partners:
mptE
Protein of unknown function DUF115; Catalyzes the transfer of diphosphate from ATP to 6- hydroxymethyl-7,8-dihydropterin (6-HMD), leading to 6-hydroxymethyl- 7,8-dihydropterin diphosphate (6-HMDP); Belongs to the archaeal 6-HMPDK family.
       0.728
dacZ
Protein of unknown function DUF147; Diadenylate cyclase that catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c-di-AMP is a second messenger for intracellular signal transduction involved in the control of important regulatory processes such as osmoregulation.
   
 0.643
ACV23983.1
PFAM: Radical SAM domain protein; SMART: Elongator protein 3/MiaB/NifB; KEGG: pub:SAR11_0383 tRNA-i(6)A37 modification enzyme.
 
     0.531
ACV24241.1
PFAM: Protein of unknown function DUF555; Belongs to the UPF0212 family.
  
     0.505
infB
Translation initiation factor aIF-2; Function in general translation initiation by promoting the binding of the formylmethionine-tRNA to ribosomes. Seems to function along with eIF-2.
  
  
 0.494
ACV24122.1
PFAM: chromosome segregation and condensation protein ScpA; KEGG: hypothetical protein LOC691864.
 
    0.490
ACV24561.1
DNA binding protein, Tfx family; Putative transcriptional regulator.
  
     0.473
ACV24151.1
PFAM: amino acid-binding ACT domain protein; KEGG: ank:AnaeK_3529 threonine dehydratase.
 
     0.433
ACV24129.1
PFAM: TatD-related deoxyribonuclease.
  
     0.416
Your Current Organism:
Methanocaldococcus fervens
NCBI taxonomy Id: 573064
Other names: M. fervens AG86, Methanocaldococcus fervens AG86, Methanocaldococcus fervens DSM 4213, Methanocaldococcus fervens str. AG86, Methanocaldococcus fervens strain AG86
Server load: low (24%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.