Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
ACV25137.1PFAM: Queuosine synthesis-like; KEGG: cjd:JJD26997_1992 hypothetical protein. (260 aa)    
Predicted Functional Partners:
trmY
Protein of unknown function DUF358; Specifically catalyzes the N1-methylation of pseudouridine at position 54 (Psi54) in tRNAs; Belongs to the methyltransferase superfamily. TrmY family.
       0.904
ACV25139.1
Phosphate uptake regulator, PhoU; PFAM: PhoU family protein; KEGG: cti:RALTA_A1971 negative regulator of PhoR/PhoB two-component regulator.
 
     0.804
ACV24037.1
TIGRFAM: pyridoxal phosphate enzyme; KEGG: spl:Spea_0442 selenocysteine synthase.
  
     0.706
ACV24193.1
PFAM: Cobyrinic acid ac-diamide synthase; CobB/CobQ domain protein glutamine amidotransferase; KEGG: gur:Gura_0041 cobyric acid synthase CobQ.
  
     0.633
ACV24411.1
PFAM: Oligosaccharyl transferase STT3 subunit; KEGG: nam:NAMH_1652 oligosaccharyl transferase, STT3 subunit.
  
     0.596
queE
Radical SAM domain protein; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds.
  
  
  0.587
ACV24658.1
PFAM: protein of unknown function DUF795; KEGG: pca:Pcar_2281 nucleotidyltransferase.
  
     0.574
ACV24134.1
PFAM: regulatory protein LysR; KEGG: pin:Ping_2047 transcriptional regulator, substrate-binding of LysR family protein.
  
     0.541
ACV25107.1
PFAM: THUMP domain protein; KEGG: ebw:BWG_0305 sulfurtransferase required for thiamine and 4-thiouridine biosynthesis.
  
     0.539
ACV24799.1
KEGG: gbm:Gbem_1676 hypothetical protein.
 
     0.532
Your Current Organism:
Methanocaldococcus fervens
NCBI taxonomy Id: 573064
Other names: M. fervens AG86, Methanocaldococcus fervens AG86, Methanocaldococcus fervens DSM 4213, Methanocaldococcus fervens str. AG86, Methanocaldococcus fervens strain AG86
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