Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
ACV25146.1PFAM: Radical SAM domain protein; SMART: Elongator protein 3/MiaB/NifB; KEGG: gsu:GSU2799 radical SAM domain-containing protein. (299 aa)    
Predicted Functional Partners:
nifH
Nitrogenase iron protein; The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex, which has 2 components: the iron protein and the molybdenum-iron protein; Belongs to the NifH/BchL/ChlL family.
 
  
 0.900
ACV24823.1
PFAM: protein of unknown function DUF366; KEGG: bba:Bd2230 hypothetical protein.
 
     0.643
queE
Radical SAM domain protein; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds.
     
 0.624
ACV24093.1
TIGRFAM: methanogenesis marker protein 2; PFAM: AIR synthase related protein; AIR synthase related protein domain protein; KEGG: mpt:Mpe_A3475 hypothetical protein.
       0.609
ACV24820.1
TIGRFAM: methanogenesis marker protein 15; CoA-substrate-specific enzyme activase; PFAM: ATPase BadF/BadG/BcrA/BcrD type; KEGG: sfu:Sfum_1829 putative CoA-substrate-specific enzyme activase.
  
    0.555
queC
exsB protein; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). Belongs to the QueC family.
     
 0.550
ACV25124.1
TIGRFAM: methanogenesis marker protein 5; PFAM: conserved hypothetical protein.
       0.536
ACV25148.1
PFAM: high-affinity nickel-transporter; KEGG: gur:Gura_2769 high-affinity nickel-transporter; Belongs to the NiCoT transporter (TC 2.A.52) family.
       0.505
ACV25125.1
TIGRFAM: methanogenesis marker protein 3; Belongs to the UPF0288 family.
 
  
 0.486
ACV24821.1
TIGRFAM: methanogenesis marker protein 17; PFAM: Uncharacterized conserved protein UCP019464, methanogenesis.
       0.422
Your Current Organism:
Methanocaldococcus fervens
NCBI taxonomy Id: 573064
Other names: M. fervens AG86, Methanocaldococcus fervens AG86, Methanocaldococcus fervens DSM 4213, Methanocaldococcus fervens str. AG86, Methanocaldococcus fervens strain AG86
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