Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
ACV25226.1TIGRFAM: phosphodiesterase, MJ0936 family; PFAM: metallophosphoesterase; KEGG: vacuolar sorting protein 29. (158 aa)    
Predicted Functional Partners:
purO
IMP cyclohydrolase; Catalyzes the cyclization of 5-formylamidoimidazole-4- carboxamide ribonucleotide to IMP.
       0.942
ACV25227.1
PFAM: 4Fe-4S ferredoxin iron-sulfur binding domain protein; KEGG: pca:Pcar_0679 ferredoxin.
       0.732
ACV24868.1
Peroxiredoxin; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.
  
 
 0.692
tfb
Transcription factor TFIIB cyclin-related; Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre-initiation complex (DNA-TBP-TFIIB).
 
    0.674
nadK
ATP-NAD/AcoX kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
  
    0.633
rlmE
Ribosomal RNA large subunit methyltransferase J; Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit.
  
    0.612
ACV24619.1
Transcriptional regulator, MarR family; PFAM: Helix-turn-helix type 11 domain protein; regulatory protein MarR; SMART: regulatory protein Crp; KEGG: asa:ASA_0900 carbohydrate kinase.
       0.609
ACV24281.1
Non-canonical purine NTP pyrophosphatase, rdgB/HAM1 family; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family.
  
  
 0.570
ACV24650.1
SMART: helicase c2; Helicase-like, DEXD box c2 type; DEAD-like helicase; KEGG: sdn:Sden_1619 helicase C2.
       0.510
ACV25230.1
PFAM: phosphate transporter; KEGG: sse:Ssed_0370 phosphate transporter.
     
 0.458
Your Current Organism:
Methanocaldococcus fervens
NCBI taxonomy Id: 573064
Other names: M. fervens AG86, Methanocaldococcus fervens AG86, Methanocaldococcus fervens DSM 4213, Methanocaldococcus fervens str. AG86, Methanocaldococcus fervens strain AG86
Server load: low (14%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.