Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
ACV25236.1TIGRFAM: CRISPR-associated HD domain protein. (235 aa)    
Predicted Functional Partners:
ACV25237.1
KEGG: dat:HRM2_05520 putative CRISPR-associated helicase Cas3 (ATP-dependent DNA helicase); TIGRFAM: CRISPR-associated helicase Cas3; PFAM: DEAD/DEAH box helicase domain protein; helicase domain protein; SMART: DEAD-like helicase; helicase domain protein.
   
 
 0.954
ACV25239.1
TIGRFAM: CRISPR-associated protein Cas5 family; PFAM: CRISPR-associated protein, MJ0382.
   
 
 0.953
ACV25240.1
TIGRFAM: CRISPR-associated regulatory protein, Csa2 family; CRISPR-associated autoregulator DevR family; PFAM: CRISPR-associated regulatory Csa2 family protein.
   
 
 0.953
ACV25235.1
Transcriptional regulator, ArsR family; TIGRFAM: CRISPR locus-related DNA-binding protein; PFAM: regulatory protein ArsR.
     
 0.909
ACV25238.1
TIGRFAM: CRISPR-associated protein (provisional), Csx9 family.
       0.905
ACV25241.1
TIGRFAM: CRISPR-associated protein, Csa5 family.
       0.900
ACV25244.1
CRISPR-associated helicase Cas3; KEGG: ebw:BWG_2497 hypothetical protein; TIGRFAM: CRISPR-associated helicase Cas3; PFAM: helicase domain protein; SMART: DEAD-like helicase; helicase domain protein.
   
 
 0.765
ACV25246.1
TIGRFAM: CRISPR-associated regulatory protein, DevR family; CRISPR-associated autoregulator DevR family.
   
 
 0.763
ACV25245.1
TIGRFAM: CRISPR-associated protein Cas5.
   
 
 0.744
cas1
CRISPR-associated protein Cas1; CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
       0.653
Your Current Organism:
Methanocaldococcus fervens
NCBI taxonomy Id: 573064
Other names: M. fervens AG86, Methanocaldococcus fervens AG86, Methanocaldococcus fervens DSM 4213, Methanocaldococcus fervens str. AG86, Methanocaldococcus fervens strain AG86
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