Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
ACV25276.1PFAM: protein of unknown function Met10; methyltransferase small; KEGG: Met-10+ like family protein. (336 aa)    
Predicted Functional Partners:
rfcL
AAA ATPase central domain protein; Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA; Belongs to the activator 1 small subunits family. RfcL subfamily.
 
    0.922
ACV25275.1
PFAM: methyltransferase small; putative RNA methylase; KEGG: vok:COSY_0362 hypothetical protein.
  
    0.891
dphB
Diphthine synthase; S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis.
 
  
 0.764
taw1
Wyosine base formation domain protein; Component of the wyosine derivatives biosynthesis pathway that catalyzes the condensation of N-methylguanine with 2 carbon atoms from pyruvate to form the tricyclic 4-demethylwyosine (imG-14) on guanosine-37 of tRNA(Phe).
 
  
 0.706
tfb
Transcription factor TFIIB cyclin-related; Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre-initiation complex (DNA-TBP-TFIIB).
 
     0.692
taw3
Protein of unknown function DUF207; S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wyosine derivatives biosynthesis pathway. Probably methylates N-4 position of wybutosine-86 to produce wybutosine-72; Belongs to the TYW3 family.
 
  
 0.678
ACV24804.1
KH domain protein; KEGG: RNA-binding protein; K06961; TIGRFAM: KH domain protein; PFAM: K Homology, type 1, subgroup; SMART: KH domain protein.
 
    0.658
ACV24959.1
Histone acetyltransferase, ELP3 family; KEGG: hypothetical protein; K07739 elongator complex protein 3; TIGRFAM: histone acetyltransferase, ELP3 family; PFAM: Radical SAM domain protein; GCN5-related N-acetyltransferase; SMART: Elongator protein 3/MiaB/NifB.
 
  
 0.646
hel308
DEAD/DEAH box helicase domain protein; DNA-dependent ATPase and 3'-5' DNA helicase that may be involved in repair of stalled replication forks.
 
     0.638
ACV24884.1
PFAM: ABC transporter related; 4Fe-4S ferredoxin iron-sulfur binding domain protein; metal-binding domain in RNase L inhibitor, RLI; SMART: AAA ATPase; KEGG: similar to ATP-binding cassette, sub-family E, member 1; K06174 ATP-binding cassette, sub-family E, member 1.
 
    0.610
Your Current Organism:
Methanocaldococcus fervens
NCBI taxonomy Id: 573064
Other names: M. fervens AG86, Methanocaldococcus fervens AG86, Methanocaldococcus fervens DSM 4213, Methanocaldococcus fervens str. AG86, Methanocaldococcus fervens strain AG86
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