Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
ACV25292.1PFAM: nucleoside recognition domain protein; KEGG: dat:HRM2_02300 hypothetical protein. (313 aa)    
Predicted Functional Partners:
taw2
Protein of unknown function Met10; S-adenosyl-L-methionine-dependent transferase that acts as a component of the wyosine derivatives biosynthesis pathway. Catalyzes the transfer of the alpha-amino-alpha-carboxypropyl (acp) group from S- adenosyl-L-methionine to 4-demethylwyosine (imG-14), forming 7- aminocarboxypropyl-demethylwyosine (wybutosine-86) at position 37 of tRNA(Phe).
 
    0.818
aspS
aspartyl-tRNA synthetase; Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn).
       0.686
ACV24551.1
PFAM: peptidase U32; KEGG: dat:HRM2_21100 putative protease.
  
     0.496
ACV24360.1
PFAM: DEAD/DEAH box helicase domain protein; Protein of unknown function DUF1998; helicase domain protein; SMART: DEAD-like helicase; helicase domain protein; KEGG: dal:Dalk_2442 DEAD/DEAH box helicase domain protein.
  
    0.482
ACV25359.1
Hypothetical protein; KEGG: eea-1; EEA1 (Early Endosome Antigen, Rab effector) homolog; K12478 early endosome antigen 1.
  
     0.443
ACV24866.1
KEGG: dde:Dde_1794 hypothetical protein.
  
     0.436
ACV25290.1
PFAM: Beta propeller domain; KEGG: mxa:MXAN_7023 putative lipoprotein.
       0.420
ACV23931.1
PFAM: Type II secretion system F domain.
  
     0.403
Your Current Organism:
Methanocaldococcus fervens
NCBI taxonomy Id: 573064
Other names: M. fervens AG86, Methanocaldococcus fervens AG86, Methanocaldococcus fervens DSM 4213, Methanocaldococcus fervens str. AG86, Methanocaldococcus fervens strain AG86
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