STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ADU13288.1KEGG: mrb:Mrub_3025 DNA-directed DNA polymerase; PFAM: UMUC domain protein DNA-repair protein. (425 aa)    
Predicted Functional Partners:
ADU11706.1
DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...]
   
 0.845
ADU14035.1
KEGG: mes:Meso_3807 hypothetical protein.
  
  
 0.737
polA
DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.
  
 0.724
lexA
Transcriptional repressor, LexA family; Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.
  
 
 0.680
recA
recA protein; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family.
  
 0.642
ADU13962.1
PFAM: peptidylprolyl isomerase FKBP-type; FKBP-type peptidyl-prolyl isomerase domain protein; KEGG: peptidylprolyl isomerase FKBP-type.
  
 
 
 0.616
ADU13289.1
PFAM: major facilitator superfamily MFS_1; KEGG: major facilitator superfamily protein.
 
     0.602
ADU13287.1
KEGG: ccs:CCNA_02345 hypothetical protein.
       0.576
ADU13286.1
KEGG: NAD-dependent epimerase/dehydratase.
       0.538
ADU14480.1
DNA polymerase III, alpha subunit; SMART: phosphoesterase PHP domain protein; TIGRFAM: DNA polymerase III, alpha subunit; KEGG: ccs:CCNA_02003 DNA polymerase III alpha subunit; PFAM: DNA polymerase III alpha subunit; nucleic acid binding OB-fold tRNA/helicase-type; PHP domain protein.
 
  
 0.506
Your Current Organism:
Asticcacaulis excentricus
NCBI taxonomy Id: 573065
Other names: A. excentricus CB 48, Asticcacaulis excentricus ATCC 15261, Asticcacaulis excentricus CB 48, Asticcacaulis excentricus DSM 4724, Asticcacaulis excentricus str. CB 48, Asticcacaulis excentricus strain CB 48
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