STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
cobBPFAM: Silent information regulator protein Sir2; KEGG: pmy:Pmen_0790 silent information regulator protein Sir2; Belongs to the sirtuin family. Class III subfamily. (236 aa)    
Predicted Functional Partners:
nadE
NAD+ synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source.
   
 0.950
nadD
Nicotinate (nicotinamide) nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).
   
 0.940
nadK
ATP-NAD/AcoX kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
  
 
 0.922
ADU13221.1
KEGG: NAD(P)(+) transhydrogenase; PFAM: alanine dehydrogenase/PNT domain protein.
     
 0.909
ADU13222.1
KEGG: NAD(P) transhydrogenase subunit alpha.
     
 0.903
ADU13955.1
KEGG: bifunctional NMN adenylyltransferase/NUDIX hydrolase; PFAM: NUDIX hydrolase; Belongs to the Nudix hydrolase family.
    
  0.902
ADU13223.1
NAD(P)(+) transhydrogenase (AB-specific); The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane; Belongs to the PNT beta subunit family.
    
  0.901
ADU14540.1
MazG family protein; KEGG: cak:Caul_2613 nucleoside triphosphate pyrophosphohydrolase; TIGRFAM: MazG family protein; PFAM: MazG nucleotide pyrophosphohydrolase.
    
  0.901
ADU13697.1
KEGG: hne:HNE_1615 leucine dehydrogenase; PFAM: Glu/Leu/Phe/Val dehydrogenase dimerisation region; Glu/Leu/Phe/Val dehydrogenase; SMART: Glu/Leu/Phe/Val dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family.
   
 0.831
ADU13293.1
TIGRFAM: gamma-glutamyltransferase; KEGG: ccs:CCNA_00565 gamma-glutamyltranspeptidase; PFAM: gamma-glutamyltranspeptidase.
 
  
 0.811
Your Current Organism:
Asticcacaulis excentricus
NCBI taxonomy Id: 573065
Other names: A. excentricus CB 48, Asticcacaulis excentricus ATCC 15261, Asticcacaulis excentricus CB 48, Asticcacaulis excentricus DSM 4724, Asticcacaulis excentricus str. CB 48, Asticcacaulis excentricus strain CB 48
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