STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
glnE(Glutamate--ammonia-ligase) adenylyltransferase; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal tra [...] (984 aa)    
Predicted Functional Partners:
glnD
UTP-GlnB uridylyltransferase, GlnD; Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen assimilation and metabolism.
 
   
 0.829
ADU14416.1
KEGG: glutamine synthetase, type I; TIGRFAM: glutamine synthetase, type I; PFAM: glutamine synthetase catalytic region; glutamine synthetase beta-Grasp.
 
  
 0.645
ADU14393.1
PFAM: alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen; KEGG: rce:RC1_1625 bacterioferritin comigratory protein, putative.
      0.613
ADU14417.1
PFAM: nitrogen regulatory protein P-II; KEGG: pzu:PHZ_c1573 nitrogen regulatory protein P-II; Belongs to the P(II) protein family.
 
 
 
 0.591
ADU13627.1
RNA polymerase, sigma-24 subunit, ECF subfamily; KEGG: ccs:CCNA_02837 RNA polymerase ECF-type sigma factor; TIGRFAM: RNA polymerase sigma factor, sigma-70 family; PFAM: sigma-70 region 2 domain protein; Sigma-70 region 4 type 2.
 
     0.551
ADU13752.1
KEGG: glutamate synthase; PFAM: ferredoxin-dependent glutamate synthase; glutamate synthase; glutamate synthase alpha subunit domain protein; glutamine amidotransferase class-II.
     
 0.523
nadE
NAD+ synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source.
  
  
 0.491
ADU13626.1
KEGG: bpy:Bphyt_5022 hypothetical protein.
       0.486
ADU14568.1
PFAM: protein of unknown function DUF177; KEGG: protein of unknown function DUF177.
  
     0.462
ADU13625.1
KEGG: bgl:bglu_2g04310 hypothetical protein.
       0.447
Your Current Organism:
Asticcacaulis excentricus
NCBI taxonomy Id: 573065
Other names: A. excentricus CB 48, Asticcacaulis excentricus ATCC 15261, Asticcacaulis excentricus CB 48, Asticcacaulis excentricus DSM 4724, Asticcacaulis excentricus str. CB 48, Asticcacaulis excentricus strain CB 48
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