STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Cooccurrence
Coexpression
Experiments
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[Homology]
Score
ADU14434.1Threonine aldolase; Catalyzes the cleavage of L-allo-threonine and L-threonine to glycine and acetaldehyde. (354 aa)    
Predicted Functional Partners:
gcvP
Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family.
    
 0.948
ADU13979.1
TIGRFAM: threonine synthase; KEGG: hne:HNE_1045 threonine synthase; PFAM: Pyridoxal-5'-phosphate-dependent protein beta subunit.
  
 0.919
glyA
Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
   
 0.918
ADU14584.1
TIGRFAM: 5-aminolevulinic acid synthase; KEGG: ccs:CCNA_01417 5-aminolevulinic acid synthase; PFAM: aminotransferase class I and II.
   
 
 0.911
ADU12484.1
KEGG: bxe:Bxe_A1314 L-threonine aldolase; PFAM: aromatic amino acid beta-eliminating lyase/threonine aldolase.
  
  
 
0.910
ADU13961.1
Threonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA.
   
 
 0.907
ADU14176.1
PFAM: aminotransferase class V; KEGG: xac:XAC0300 serine-pyruvate aminotransferase.
    
 0.830
ADU14433.1
Hypothetical protein; KEGG: rba:RB13147 arylsulphatase A.
       0.501
ADU12848.1
PFAM: homoserine dehydrogenase; aspartate/glutamate/uridylate kinase; homoserine dehydrogenase NAD-binding; KEGG: mmr:Mmar10_1098 aspartate kinase, homoserine dehydrogenase.
  
  
 0.456
ADU13766.1
HAD-superfamily hydrolase, subfamily IB (PSPase-like); Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L- serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.
     
 0.419
Your Current Organism:
Asticcacaulis excentricus
NCBI taxonomy Id: 573065
Other names: A. excentricus CB 48, Asticcacaulis excentricus ATCC 15261, Asticcacaulis excentricus CB 48, Asticcacaulis excentricus DSM 4724, Asticcacaulis excentricus str. CB 48, Asticcacaulis excentricus strain CB 48
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