node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
DMR_04880 | DMR_29730 | DMR_04880 | DMR_29730 | Heat shock protein DnaJ family protein. | Heat shock protein Hsp70 family protein. | 0.936 |
DMR_04880 | clpP | DMR_04880 | DMR_28170 | Heat shock protein DnaJ family protein. | ATP-dependent Clp protease proteolytic subunit; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | 0.619 |
DMR_04880 | dnaK | DMR_04880 | DMR_17370 | Heat shock protein DnaJ family protein. | Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.993 |
DMR_04880 | groEL | DMR_04880 | DMR_02710 | Heat shock protein DnaJ family protein. | 60 kDa chaperonin; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | 0.867 |
DMR_04880 | groES | DMR_04880 | DMR_02720 | Heat shock protein DnaJ family protein. | 10 kDa chaperonin; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter. | 0.781 |
DMR_04880 | grpE | DMR_04880 | DMR_17380 | Heat shock protein DnaJ family protein. | Protein GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent i [...] | 0.961 |
DMR_04880 | guaB | DMR_04880 | DMR_22400 | Heat shock protein DnaJ family protein. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.401 |
DMR_04880 | hslU | DMR_04880 | DMR_38380 | Heat shock protein DnaJ family protein. | ATP-dependent hsl protease ATP-binding subunit HslU; ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis. | 0.850 |
DMR_04880 | htpG | DMR_04880 | DMR_11440 | Heat shock protein DnaJ family protein. | Chaperone protein HtpG; Molecular chaperone. Has ATPase activity. | 0.952 |
DMR_29730 | DMR_04880 | DMR_29730 | DMR_04880 | Heat shock protein Hsp70 family protein. | Heat shock protein DnaJ family protein. | 0.936 |
DMR_29730 | clpP | DMR_29730 | DMR_28170 | Heat shock protein Hsp70 family protein. | ATP-dependent Clp protease proteolytic subunit; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | 0.781 |
DMR_29730 | dnaJ | DMR_29730 | DMR_19970 | Heat shock protein Hsp70 family protein. | Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...] | 0.946 |
DMR_29730 | groEL | DMR_29730 | DMR_02710 | Heat shock protein Hsp70 family protein. | 60 kDa chaperonin; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | 0.954 |
DMR_29730 | groES | DMR_29730 | DMR_02720 | Heat shock protein Hsp70 family protein. | 10 kDa chaperonin; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter. | 0.939 |
DMR_29730 | grpE | DMR_29730 | DMR_17380 | Heat shock protein Hsp70 family protein. | Protein GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent i [...] | 0.976 |
DMR_29730 | guaB | DMR_29730 | DMR_22400 | Heat shock protein Hsp70 family protein. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.568 |
DMR_29730 | hslU | DMR_29730 | DMR_38380 | Heat shock protein Hsp70 family protein. | ATP-dependent hsl protease ATP-binding subunit HslU; ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis. | 0.709 |
DMR_29730 | htpG | DMR_29730 | DMR_11440 | Heat shock protein Hsp70 family protein. | Chaperone protein HtpG; Molecular chaperone. Has ATPase activity. | 0.990 |
clpP | DMR_04880 | DMR_28170 | DMR_04880 | ATP-dependent Clp protease proteolytic subunit; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | Heat shock protein DnaJ family protein. | 0.619 |
clpP | DMR_29730 | DMR_28170 | DMR_29730 | ATP-dependent Clp protease proteolytic subunit; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | Heat shock protein Hsp70 family protein. | 0.781 |