STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
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Textmining
[Homology]
Score
ADK79260.1COGs: COG1435 Thymidine kinase; KEGG: bdu:BDU_798 thymidine kinase; SPTR: Thymidine kinase; PFAM: Thymidine kinase. (382 aa)    
Predicted Functional Partners:
dut
Deoxyuridine 5'-triphosphate nucleotidohydrolase Dut; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family.
   
 
 0.980
tmk
Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family.
  
 
 0.940
ADK83230.1
COGs: COG0213 Thymidine phosphorylase; InterProIPR017459:IPR000312:IPR013102:IPR017872:IPR 018090:IPR000053; KEGG: drm:Dred_1101 pyrimidine-nucleoside phosphorylase; PFAM: glycosyl transferase family 3; Glycosyl transferase, family 3-like; Pyrimidine nucleoside phosphorylase domain; PRIAM: Pyrimidine-nucleoside phosphorylase; SPTR: Thymidine phosphorylase; TIGRFAM: pyrimidine-nucleoside phosphorylase; PFAM: Pyrimidine nucleoside phosphorylase C-terminal domain; Glycosyl transferase family, a/b domain; Glycosyl transferase family, helical bundle domain; TIGRFAM: pyrimidine-nucleoside ph [...]
    
 0.931
ADK81773.1
Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family.
    
 0.927
thyX
Thymidylate synthase, flavin-dependent; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant.
    
 0.922
ADK82455.1
COGs: COG2820 Uridine phosphorylase; InterPro IPR000845:IPR018016; KEGG: pmo:Pmob_0304 purine phosphorylase family 1; PFAM: purine or other phosphorylase family 1; SPTR: Purine or other phosphorylase family 1; PFAM: Phosphorylase superfamily; TIGRFAM: purine-nucleoside phosphorylase, family 1 (deoD).
     
 0.913
ADK83005.1
COGs: COG2820 Uridine phosphorylase; InterPro IPR018016:IPR000845; KEGG: str:Sterm_0544 purine or other phosphorylase family 1; PFAM: purine or other phosphorylase family 1; SPTR: Putative uncharacterized protein; PFAM: Phosphorylase superfamily; TIGRFAM: uridine phosphorylase.
     
 0.913
ADK83219.1
Purine nucleoside phosphorylase I, inosine and guanosine-specific; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.
    
  0.911
ADK79774.1
Metallophosphoesterase; COGs: COG0737 5'-nucleotidase/2' 3'-cyclic phosphodiesterase and related esterase; InterPro IPR004843:IPR018282:IPR006179; KEGG: syp:SYNPCC7002_A0150 Ser/Thr protein phosphatase family protein; PFAM: metallophosphoesterase; SPTR: Ser/Thr protein phosphatase family protein; PFAM: 5'-nucleotidase, C-terminal domain; Belongs to the 5'-nucleotidase family.
    
 0.905
ADK80176.1
COGs: COG0737 5'-nucleotidase/2' 3'-cyclic phosphodiesterase and related esterase; InterPro IPR006146:IPR004843:IPR008334:IPR006179; KEGG: taf:THA_358 bifunctional UDP-sugar hydrolase/5'-nucleotidase periplasmic precursor; PFAM: 5'-Nucleotidase domain protein; metallophosphoesterase; PRIAM: 5'-nucleotidase; SPTR: Protein UshA; PFAM: 5'-nucleotidase, C-terminal domain; Calcineurin-like phosphoesterase; Belongs to the 5'-nucleotidase family.
    
 0.905
Your Current Organism:
Sediminispirochaeta smaragdinae
NCBI taxonomy Id: 573413
Other names: S. smaragdinae DSM 11293, Sediminispirochaeta smaragdinae DSM 11293, Spirochaeta smaragdinae DSM 11293
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