STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ADK79577.1D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding protein; COGs: COG0111 Phosphoglycerate dehydrogenase and related dehydrogenase; InterPro IPR006139:IPR006140; KEGG: dtu:Dtur_1775 D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding; PFAM: D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding; D-isomer specific 2-hydroxyacid dehydrogenase catalytic region; SPTR: D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding; PFAM: D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain; D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain. (312 aa)    
Predicted Functional Partners:
ADK79576.1
Alcohol dehydrogenase GroES domain protein; COGs: COG1063 Threonine dehydrogenase and related Zn-dependent dehydrogenase; InterPro IPR013154:IPR013149; KEGG: mjl:Mjls_2811 alcohol dehydrogenase; PFAM: Alcohol dehydrogenase GroES domain protein; Alcohol dehydrogenase zinc-binding domain protein; SPTR: Alcohol dehydrogenase GroES domain protein; PFAM: Alcohol dehydrogenase GroES-like domain; Zinc-binding dehydrogenase; TIGRFAM: 2-desacetyl-2-hydroxyethyl bacteriochlorophyllide A dehydrogenase.
     
 0.785
ADK79578.1
COGs: COG3181 conserved hypothetical protein; InterPro IPR005064; KEGG: cpy:Cphy_0596 hypothetical protein; PFAM: conserved hypothetical protein; SPTR: Putative uncharacterized protein; PFAM: Tripartite tricarboxylate transporter family receptor.
       0.778
serC
Phosphoserine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily.
  
 
 0.660
ADK81874.1
COGs: COG0527 Aspartokinase; InterProIPR001341:IPR001048:IPR002912:IPR005106:IPR 001342:IPR011147:IPR001412:IPR019811; KEGG: sru:SRU_0691 bifunctional aspartokinase I/homeserine dehydrogenase I; PFAM: homoserine dehydrogenase; homoserine dehydrogenase NAD-binding; aspartate/glutamate/uridylate kinase; amino acid-binding ACT domain protein; SPTR: Bifunctional aspartokinase/homoserine dehydrogenase I; TIGRFAM: aspartate kinase; PFAM: Homoserine dehydrogenase, NAD binding domain; Homoserine dehydrogenase; ACT domain; Amino acid kinase family; TIGRFAM: glutamate--cysteine ligase/gamma-glut [...]
  
 
 0.655
ADK83358.1
Homocysteine S-methyltransferase; COGs: COG0646 Methionine synthase I (cobalamin-dependent) methyltransferase domain; InterPro IPR003726:IPR003171; KEGG: sus:Acid_7115 bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein; PFAM: homocysteine S-methyltransferase; methylenetetrahydrofolate reductase; SPTR: Methylenetetrahydrofolate reductase; PFAM: Methylenetetrahydrofolate reductase; Homocysteine S-methyltransferase.
   
 
 0.651
ADK79579.1
KEGG: dtu:Dtur_0299 hypothetical protein; SPTR: Putative uncharacterized protein.
       0.634
ADK79580.1
Protein of unknown function DUF112 transmembrane; COGs: COG3333 conserved hypothetical protein; InterPro IPR002823; KEGG: tle:Tlet_1876 hypothetical protein; PFAM: protein of unknown function DUF112 transmembrane; SPTR: Putative uncharacterized protein; PFAM: Tripartite tricarboxylate transporter TctA family.
       0.586
ADK79575.1
Short-chain dehydrogenase/reductase SDR; COGs: COG1028 Dehydrogenase with different specificities (related to short-chain alcohol dehydrogenase); InterPro IPR002347:IPR002198; KEGG: ect:ECIAI39_0671 putative short-chain dehydrogenase/reductase SDR precursor; PFAM: short-chain dehydrogenase/reductase SDR; SPTR: 3-oxoacyl-[acyl-carrier-protein] reductase; PFAM: short chain dehydrogenase.
  
 
 0.581
rplP
Ribosomal protein L16; Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs; Belongs to the universal ribosomal protein uL16 family.
   
   0.550
rplV
Ribosomal protein L22; The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
    
 
 0.512
Your Current Organism:
Sediminispirochaeta smaragdinae
NCBI taxonomy Id: 573413
Other names: S. smaragdinae DSM 11293, Sediminispirochaeta smaragdinae DSM 11293, Spirochaeta smaragdinae DSM 11293
Server load: low (22%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.