STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ADK80530.1COGs: COG3920 Signal transduction histidine kinase; InterProIPR018771:IPR013656:IPR011495:IPR003594:IPR 000014; KEGG: cts:Ctha_0145 signal transduction histidine kinase; PFAM: Transcriptional regulator, histidine kinase sensor-like; PAS fold-4 domain protein; histidine kinase dimerisation/phosphoacceptor; ATP-binding region ATPase domain protein; SMART: ATP-binding region ATPase domain protein; SPTR: Sensor protein; TIGRFAM: PAS sensor protein; PFAM: Histidine kinase; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Predicted histidine kinase sensor domain; PAS fold; TIGRFAM: P [...] (527 aa)    
Predicted Functional Partners:
ADK81232.1
COGs: COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain; InterPro IPR001789; KEGG: lbf:LBF_2370 signal transduction histidine kinase; PFAM: response regulator receiver; SMART: response regulator receiver; SPTR: Putative two-component response regulator; PFAM: Response regulator receiver domain.
     0.793
ADK82981.1
COGs: COG2204 Response regulator containing CheY-like receiver AAA-type ATPase and DNA-binding domains; InterPro IPR001789; KEGG: azl:AZL_b02970 two-component hybrid sensor and regulator; PFAM: response regulator receiver; SMART: response regulator receiver; SPTR: Two-component hybrid sensor and regulator; PFAM: Response regulator receiver domain.
 
  
 0.793
ADK80950.1
COGs: COG4585 Signal transduction histidine kinase; InterProIPR000014:IPR001789:IPR013767:IPR011712:IPR 003594:IPR019775:IPR005467:IPR000700; KEGG: sru:SRU_0678 sensor protein FixL; PFAM: response regulator receiver; PAS fold domain protein; histidine kinase dimerisation and phosphoacceptor region; ATP-binding region ATPase domain protein; SMART: response regulator receiver; PAS domain containing protein; ATP-binding region ATPase domain protein; SPTR: Sensor protein fixL; TIGRFAM: PAS sensor protein; PFAM: Histidine kinase; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Resp [...]
  
 0.766
ADK80953.1
COGs: COG4191 Signal transduction histidine kinase regulating C4-dicarboxylate transport system; InterProIPR000014:IPR004358:IPR001789:IPR013767:IPR 003661:IPR003594:IPR005467:IPR000700; KEGG: sfu:Sfum_3112 putative PAS/PAC sensor protein; PFAM: ATP-binding region ATPase domain protein; response regulator receiver; PAS fold domain protein; histidine kinase A domain protein; SMART: ATP-binding region ATPase domain protein; response regulator receiver; PAS domain containing protein; histidine kinase A domain protein; SPTR: Sensor protein; TIGRFAM: PAS sensor protein; PFAM: Histidine kina [...]
  
 0.584
ADK80576.1
COGs: COG2200 FOG: EAL domain; InterProIPR001789:IPR013767:IPR000160:IPR001633:IPR 000014; KEGG: tgr:Tgr7_1990 diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(s); PFAM: EAL domain protein; GGDEF domain containing protein; response regulator receiver; PAS fold domain protein; SMART: EAL domain protein; GGDEF domain containing protein; response regulator receiver; PAS domain containing protein; SPTR: Response regulator receiver modulated diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S); TIGRFAM: diguanylate cyclase; PAS sensor protein; PFAM: EAL domain; GGDEF domain [...]
  
 0.546
ADK82627.1
COGs: COG3920 Signal transduction histidine kinase; InterProIPR001789:IPR000014:IPR001610:IPR013655:IPR 013767:IPR011495:IPR003594:IPR005467:IPR000700:IPR001385; KEGG: cyn:Cyan7425_4138 signal transduction histidine kinase; PFAM: PAS fold-3 domain protein; response regulator receiver; PAS fold domain protein; histidine kinase dimerisation/phosphoacceptor; ATP-binding region ATPase domain protein; SMART: response regulator receiver; PAS domain containing protein; PAC repeat-containing protein; SPTR: Signal transduction histidine kinase; TIGRFAM: PAS sensor protein; PFAM: Histidine kinas [...]
 
  
0.506
ADK82438.1
COGs: COG4191 Signal transduction histidine kinase regulating C4-dicarboxylate transport system; InterProIPR000014:IPR003594:IPR001789:IPR005467:IPR 004358:IPR013767; KEGG: dal:Dalk_1499 PAS/PAC sensor hybrid histidine kinase; PFAM: ATP-binding region ATPase domain protein; PAS fold domain protein; response regulator receiver; SMART: ATP-binding region ATPase domain protein; PAS domain containing protein; response regulator receiver; SPTR: Sensor protein; TIGRFAM: PAS sensor protein; PFAM: Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Response regulator receiver domain; PAS [...]
 
  
 0.470
ADK80538.1
COGs: COG4191 Signal transduction histidine kinase regulating C4-dicarboxylate transport system; InterProIPR004358:IPR001789:IPR003018:IPR003594:IPR 005467; KEGG: glo:Glov_0071 integral membrane sensor signal transduction histidine kinase; PFAM: ATP-binding region ATPase domain protein; response regulator receiver; GAF domain protein; SMART: ATP-binding region ATPase domain protein; response regulator receiver; SPTR: Sensor protein; PFAM: Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Response regulator receiver domain; His Kinase A (phosphoacceptor) domain.
 
  
 0.439
ADK80531.1
KEGG: tde:TDE2433 treponemal membrane protein, putative; SPTR: Treponemal membrane protein, putative.
       0.436
ADK80532.1
Hypothetical protein; KEGG: lma:LmjF27.0240 kinetoplast-associated protein-like protein; SPTR: Kinetoplast-associated protein-like protein.
       0.436
Your Current Organism:
Sediminispirochaeta smaragdinae
NCBI taxonomy Id: 573413
Other names: S. smaragdinae DSM 11293, Sediminispirochaeta smaragdinae DSM 11293, Spirochaeta smaragdinae DSM 11293
Server load: low (26%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.