node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ADK79752.1 | ADK81505.1 | Spirs_0608 | Spirs_2391 | Homocysteine S-methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Class II aldolase/adducin family protein; COGs: COG0235 Ribulose-5-phosphate 4-epimerase and related epimerase and aldolase; InterPro IPR001303; KEGG: rba:RB681 L-fuculose-phosphate aldolase; PFAM: class II aldolase/adducin family protein; SPTR: Putative uncharacterized protein; PFAM: Class II Aldolase and Adducin N-terminal domain. | 0.409 |
ADK79752.1 | ADK81508.1 | Spirs_0608 | Spirs_2394 | Homocysteine S-methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | eIF-2B alpha/beta/delta-related uncharacterized protein; COGs: COG0182 translation initiation factor 2B subunit eIF-2B alpha/beta/delta family; InterPro IPR000649:IPR011559; KEGG: ctc:CTC00945 methylthioribose-1-phosphate isomerase; PFAM: initiation factor 2B related; PRIAM: S-methyl-5-thioribose-1-phosphate isomerase; SPTR: Putative translation initiation factor EIF-2B subunit 1; TIGRFAM: eIF-2B alpha/beta/delta-related uncharacterized protein; PFAM: Initiation factor 2 subunit family; TIGRFAM: eIF-2B alpha/beta/delta-related uncharacterized proteins; Belongs to the eIF-2B alpha/beta/ [...] | 0.669 |
ADK79752.1 | ADK82972.1 | Spirs_0608 | Spirs_3887 | Homocysteine S-methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | eIF-2B alpha/beta/delta-related uncharacterized protein; COGs: COG0182 translation initiation factor 2B subunit eIF-2B alpha/beta/delta family; InterPro IPR000649:IPR011559; KEGG: amt:Amet_3757 methylthioribose-1-phosphate isomerase; PFAM: initiation factor 2B related; PRIAM: S-methyl-5-thioribose-1-phosphate isomerase; SPTR: Putative uncharacterized protein; TIGRFAM: eIF-2B alpha/beta/delta-related uncharacterized protein; PFAM: Initiation factor 2 subunit family; TIGRFAM: eIF-2B alpha/beta/delta-related uncharacterized proteins; Belongs to the eIF-2B alpha/beta/delta subunits family. | 0.669 |
ADK79752.1 | ADK83358.1 | Spirs_0608 | Spirs_4285 | Homocysteine S-methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Homocysteine S-methyltransferase; COGs: COG0646 Methionine synthase I (cobalamin-dependent) methyltransferase domain; InterPro IPR003726:IPR003171; KEGG: sus:Acid_7115 bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein; PFAM: homocysteine S-methyltransferase; methylenetetrahydrofolate reductase; SPTR: Methylenetetrahydrofolate reductase; PFAM: Methylenetetrahydrofolate reductase; Homocysteine S-methyltransferase. | 0.998 |
ADK79752.1 | mtnA | Spirs_0608 | Spirs_1423 | Homocysteine S-methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Translation initiation factor, aIF-2BI family; Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). | 0.669 |
ADK79752.1 | mtnK | Spirs_0608 | Spirs_2395 | Homocysteine S-methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 5-methylthioribose kinase; Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate. | 0.540 |
ADK79954.1 | ADK81508.1 | Spirs_0819 | Spirs_2394 | COGs: COG0036 Pentose-5-phosphate-3-epimerase; InterPro IPR000056; KEGG: rle:pRL120033 putative D-allulose-6-phosphate 3-epimerase; PFAM: ribulose-phosphate 3-epimerase; PRIAM: Ribulose-phosphate 3-epimerase; SPTR: Putative D-allulose-6-phosphate 3-epimerase; PFAM: Ribulose-phosphate 3 epimerase family; TIGRFAM: ribulose-phosphate 3-epimerase. | eIF-2B alpha/beta/delta-related uncharacterized protein; COGs: COG0182 translation initiation factor 2B subunit eIF-2B alpha/beta/delta family; InterPro IPR000649:IPR011559; KEGG: ctc:CTC00945 methylthioribose-1-phosphate isomerase; PFAM: initiation factor 2B related; PRIAM: S-methyl-5-thioribose-1-phosphate isomerase; SPTR: Putative translation initiation factor EIF-2B subunit 1; TIGRFAM: eIF-2B alpha/beta/delta-related uncharacterized protein; PFAM: Initiation factor 2 subunit family; TIGRFAM: eIF-2B alpha/beta/delta-related uncharacterized proteins; Belongs to the eIF-2B alpha/beta/ [...] | 0.518 |
ADK79954.1 | ADK82972.1 | Spirs_0819 | Spirs_3887 | COGs: COG0036 Pentose-5-phosphate-3-epimerase; InterPro IPR000056; KEGG: rle:pRL120033 putative D-allulose-6-phosphate 3-epimerase; PFAM: ribulose-phosphate 3-epimerase; PRIAM: Ribulose-phosphate 3-epimerase; SPTR: Putative D-allulose-6-phosphate 3-epimerase; PFAM: Ribulose-phosphate 3 epimerase family; TIGRFAM: ribulose-phosphate 3-epimerase. | eIF-2B alpha/beta/delta-related uncharacterized protein; COGs: COG0182 translation initiation factor 2B subunit eIF-2B alpha/beta/delta family; InterPro IPR000649:IPR011559; KEGG: amt:Amet_3757 methylthioribose-1-phosphate isomerase; PFAM: initiation factor 2B related; PRIAM: S-methyl-5-thioribose-1-phosphate isomerase; SPTR: Putative uncharacterized protein; TIGRFAM: eIF-2B alpha/beta/delta-related uncharacterized protein; PFAM: Initiation factor 2 subunit family; TIGRFAM: eIF-2B alpha/beta/delta-related uncharacterized proteins; Belongs to the eIF-2B alpha/beta/delta subunits family. | 0.518 |
ADK79954.1 | mtnA | Spirs_0819 | Spirs_1423 | COGs: COG0036 Pentose-5-phosphate-3-epimerase; InterPro IPR000056; KEGG: rle:pRL120033 putative D-allulose-6-phosphate 3-epimerase; PFAM: ribulose-phosphate 3-epimerase; PRIAM: Ribulose-phosphate 3-epimerase; SPTR: Putative D-allulose-6-phosphate 3-epimerase; PFAM: Ribulose-phosphate 3 epimerase family; TIGRFAM: ribulose-phosphate 3-epimerase. | Translation initiation factor, aIF-2BI family; Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). | 0.518 |
ADK81505.1 | ADK79752.1 | Spirs_2391 | Spirs_0608 | Class II aldolase/adducin family protein; COGs: COG0235 Ribulose-5-phosphate 4-epimerase and related epimerase and aldolase; InterPro IPR001303; KEGG: rba:RB681 L-fuculose-phosphate aldolase; PFAM: class II aldolase/adducin family protein; SPTR: Putative uncharacterized protein; PFAM: Class II Aldolase and Adducin N-terminal domain. | Homocysteine S-methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.409 |
ADK81505.1 | ADK81506.1 | Spirs_2391 | Spirs_2392 | Class II aldolase/adducin family protein; COGs: COG0235 Ribulose-5-phosphate 4-epimerase and related epimerase and aldolase; InterPro IPR001303; KEGG: rba:RB681 L-fuculose-phosphate aldolase; PFAM: class II aldolase/adducin family protein; SPTR: Putative uncharacterized protein; PFAM: Class II Aldolase and Adducin N-terminal domain. | Carbohydrate kinase, FGGY; COGs: COG1070 Sugar (pentulose and hexulose) kinase; InterPro IPR018484; KEGG: phe:Phep_3504 carbohydrate kinase FGGY; PFAM: Carbohydrate kinase, FGGY-like; SPTR: Putative uncharacterized protein; PFAM: FGGY family of carbohydrate kinases, N-terminal domain; FGGY family of carbohydrate kinases, C-terminal domain. | 0.829 |
ADK81505.1 | ADK81507.1 | Spirs_2391 | Spirs_2393 | Class II aldolase/adducin family protein; COGs: COG0235 Ribulose-5-phosphate 4-epimerase and related epimerase and aldolase; InterPro IPR001303; KEGG: rba:RB681 L-fuculose-phosphate aldolase; PFAM: class II aldolase/adducin family protein; SPTR: Putative uncharacterized protein; PFAM: Class II Aldolase and Adducin N-terminal domain. | D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding protein; COGs: COG0111 Phosphoglycerate dehydrogenase and related dehydrogenase; InterPro IPR006139:IPR006140; KEGG: phe:Phep_3505 D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding; PFAM: D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding; D-isomer specific 2-hydroxyacid dehydrogenase catalytic region; SPTR: Putative uncharacterized protein; PFAM: D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain; D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain. | 0.814 |
ADK81505.1 | ADK81508.1 | Spirs_2391 | Spirs_2394 | Class II aldolase/adducin family protein; COGs: COG0235 Ribulose-5-phosphate 4-epimerase and related epimerase and aldolase; InterPro IPR001303; KEGG: rba:RB681 L-fuculose-phosphate aldolase; PFAM: class II aldolase/adducin family protein; SPTR: Putative uncharacterized protein; PFAM: Class II Aldolase and Adducin N-terminal domain. | eIF-2B alpha/beta/delta-related uncharacterized protein; COGs: COG0182 translation initiation factor 2B subunit eIF-2B alpha/beta/delta family; InterPro IPR000649:IPR011559; KEGG: ctc:CTC00945 methylthioribose-1-phosphate isomerase; PFAM: initiation factor 2B related; PRIAM: S-methyl-5-thioribose-1-phosphate isomerase; SPTR: Putative translation initiation factor EIF-2B subunit 1; TIGRFAM: eIF-2B alpha/beta/delta-related uncharacterized protein; PFAM: Initiation factor 2 subunit family; TIGRFAM: eIF-2B alpha/beta/delta-related uncharacterized proteins; Belongs to the eIF-2B alpha/beta/ [...] | 0.901 |
ADK81505.1 | ADK81510.1 | Spirs_2391 | Spirs_2396 | Class II aldolase/adducin family protein; COGs: COG0235 Ribulose-5-phosphate 4-epimerase and related epimerase and aldolase; InterPro IPR001303; KEGG: rba:RB681 L-fuculose-phosphate aldolase; PFAM: class II aldolase/adducin family protein; SPTR: Putative uncharacterized protein; PFAM: Class II Aldolase and Adducin N-terminal domain. | COGs: COG1757 Na+/H+ antiporter; InterPro IPR018461; KEGG: fnu:FN1414 Na+/H+ antiporter NhaC; PFAM: Na+/H+ antiporter NhaC-like; SPTR: Putative uncharacterized protein; PFAM: Na+/H+ antiporter family. | 0.566 |
ADK81505.1 | ADK82972.1 | Spirs_2391 | Spirs_3887 | Class II aldolase/adducin family protein; COGs: COG0235 Ribulose-5-phosphate 4-epimerase and related epimerase and aldolase; InterPro IPR001303; KEGG: rba:RB681 L-fuculose-phosphate aldolase; PFAM: class II aldolase/adducin family protein; SPTR: Putative uncharacterized protein; PFAM: Class II Aldolase and Adducin N-terminal domain. | eIF-2B alpha/beta/delta-related uncharacterized protein; COGs: COG0182 translation initiation factor 2B subunit eIF-2B alpha/beta/delta family; InterPro IPR000649:IPR011559; KEGG: amt:Amet_3757 methylthioribose-1-phosphate isomerase; PFAM: initiation factor 2B related; PRIAM: S-methyl-5-thioribose-1-phosphate isomerase; SPTR: Putative uncharacterized protein; TIGRFAM: eIF-2B alpha/beta/delta-related uncharacterized protein; PFAM: Initiation factor 2 subunit family; TIGRFAM: eIF-2B alpha/beta/delta-related uncharacterized proteins; Belongs to the eIF-2B alpha/beta/delta subunits family. | 0.581 |
ADK81505.1 | ADK83358.1 | Spirs_2391 | Spirs_4285 | Class II aldolase/adducin family protein; COGs: COG0235 Ribulose-5-phosphate 4-epimerase and related epimerase and aldolase; InterPro IPR001303; KEGG: rba:RB681 L-fuculose-phosphate aldolase; PFAM: class II aldolase/adducin family protein; SPTR: Putative uncharacterized protein; PFAM: Class II Aldolase and Adducin N-terminal domain. | Homocysteine S-methyltransferase; COGs: COG0646 Methionine synthase I (cobalamin-dependent) methyltransferase domain; InterPro IPR003726:IPR003171; KEGG: sus:Acid_7115 bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein; PFAM: homocysteine S-methyltransferase; methylenetetrahydrofolate reductase; SPTR: Methylenetetrahydrofolate reductase; PFAM: Methylenetetrahydrofolate reductase; Homocysteine S-methyltransferase. | 0.443 |
ADK81505.1 | mtnA | Spirs_2391 | Spirs_1423 | Class II aldolase/adducin family protein; COGs: COG0235 Ribulose-5-phosphate 4-epimerase and related epimerase and aldolase; InterPro IPR001303; KEGG: rba:RB681 L-fuculose-phosphate aldolase; PFAM: class II aldolase/adducin family protein; SPTR: Putative uncharacterized protein; PFAM: Class II Aldolase and Adducin N-terminal domain. | Translation initiation factor, aIF-2BI family; Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). | 0.547 |
ADK81505.1 | mtnK | Spirs_2391 | Spirs_2395 | Class II aldolase/adducin family protein; COGs: COG0235 Ribulose-5-phosphate 4-epimerase and related epimerase and aldolase; InterPro IPR001303; KEGG: rba:RB681 L-fuculose-phosphate aldolase; PFAM: class II aldolase/adducin family protein; SPTR: Putative uncharacterized protein; PFAM: Class II Aldolase and Adducin N-terminal domain. | 5-methylthioribose kinase; Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate. | 0.737 |
ADK81506.1 | ADK81505.1 | Spirs_2392 | Spirs_2391 | Carbohydrate kinase, FGGY; COGs: COG1070 Sugar (pentulose and hexulose) kinase; InterPro IPR018484; KEGG: phe:Phep_3504 carbohydrate kinase FGGY; PFAM: Carbohydrate kinase, FGGY-like; SPTR: Putative uncharacterized protein; PFAM: FGGY family of carbohydrate kinases, N-terminal domain; FGGY family of carbohydrate kinases, C-terminal domain. | Class II aldolase/adducin family protein; COGs: COG0235 Ribulose-5-phosphate 4-epimerase and related epimerase and aldolase; InterPro IPR001303; KEGG: rba:RB681 L-fuculose-phosphate aldolase; PFAM: class II aldolase/adducin family protein; SPTR: Putative uncharacterized protein; PFAM: Class II Aldolase and Adducin N-terminal domain. | 0.829 |
ADK81506.1 | ADK81507.1 | Spirs_2392 | Spirs_2393 | Carbohydrate kinase, FGGY; COGs: COG1070 Sugar (pentulose and hexulose) kinase; InterPro IPR018484; KEGG: phe:Phep_3504 carbohydrate kinase FGGY; PFAM: Carbohydrate kinase, FGGY-like; SPTR: Putative uncharacterized protein; PFAM: FGGY family of carbohydrate kinases, N-terminal domain; FGGY family of carbohydrate kinases, C-terminal domain. | D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding protein; COGs: COG0111 Phosphoglycerate dehydrogenase and related dehydrogenase; InterPro IPR006139:IPR006140; KEGG: phe:Phep_3505 D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding; PFAM: D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding; D-isomer specific 2-hydroxyacid dehydrogenase catalytic region; SPTR: Putative uncharacterized protein; PFAM: D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain; D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain. | 0.823 |