STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
cheB-2Response regulator receiver modulated CheB methylesterase; Involved in chemotaxis. Part of a chemotaxis signal transduction system that modulates chemotaxis in response to various stimuli. Catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins or MCP) by CheR. Also mediates the irreversible deamidation of specific glutamine residues to glutamic acid. Belongs to the CheB family. (352 aa)    
Predicted Functional Partners:
ADK82017.1
CheA signal transduction histidine kinase; COGs: COG0643 Chemotaxis protein histidine kinase and related kinase; InterProIPR008207:IPR004105:IPR003594:IPR002545:IPR 004358:IPR005467; KEGG: dal:Dalk_3929 CheA signal transduction histidine kinase; PFAM: ATP-binding region ATPase domain protein; Hpt domain protein; Signal transducing histidine kinase homodimeric; CheW domain protein; SMART: ATP-binding region ATPase domain protein; Hpt domain protein; CheW domain protein; SPTR: CheA signal transduction histidine kinases; PFAM: CheW-like domain; Histidine kinase-, DNA gyrase B-, and HSP90- [...]
 0.998
ADK82024.1
MCP methyltransferase, CheR-type; COGs: COG0835 Chemotaxis signal transduction protein; InterPro IPR002545:IPR000780; KEGG: tpp:TPASS_0364 purine-binding chemotaxis protein; PFAM: MCP methyltransferase CheR-type; CheW domain protein; SMART: CheW domain protein; MCP methyltransferase CheR-type; SPTR: Chemotaxis protein CheW; PFAM: CheW-like domain; CheR methyltransferase, SAM binding domain.
 
 
 0.996
ADK82025.1
CheA signal transduction histidine kinase; COGs: COG0643 Chemotaxis protein histidine kinase and related kinase; InterProIPR008207:IPR010808:IPR004105:IPR003594:IPR 002545:IPR004358:IPR005467; KEGG: tde:TDE1491 chemotaxis protein CheA; PFAM: CheW domain protein; ATP-binding region ATPase domain protein; P2 response regulator binding domain protein; Hpt domain protein; Signal transducing histidine kinase homodimeric; SMART: CheW domain protein; Hpt domain protein; ATP-binding region ATPase domain protein; SPTR: P2 response regulator binding domain protein; PFAM: P2 response regulator bi [...]
 0.996
ADK80947.1
CheA signal transduction histidine kinase; COGs: COG0643 Chemotaxis protein histidine kinase and related kinase; InterProIPR004358:IPR008207:IPR004105:IPR003594:IPR 002545:IPR005467; KEGG: gsu:GSU1290 chemotaxis protein CheA; PFAM: ATP-binding region ATPase domain protein; Hpt domain protein; Signal transducing histidine kinase homodimeric; CheW domain protein; SMART: Hpt domain protein; ATP-binding region ATPase domain protein; CheW domain protein; SPTR: Chemotaxis protein CheA; PFAM: CheW-like domain; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Signal transducing histidi [...]
 0.995
ADK80719.1
CheA signal transduction histidine kinase; COGs: COG0643 Chemotaxis protein histidine kinase and related kinase; InterProIPR004358:IPR003594:IPR010916:IPR008207:IPR 005467; KEGG: tte:TTE1417 chemotaxis protein histidine kinase-like kinase; PFAM: ATP-binding region ATPase domain protein; SMART: ATP-binding region ATPase domain protein; Hpt domain protein; SPTR: Chemotaxis protein histidine kinase and related kinases; PFAM: P2 response regulator binding domain; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Hpt domain.
 
 0.994
ADK82016.1
MCP methyltransferase, CheR-type; COGs: COG1352 Methylase of chemotaxis methyl-accepting protein; InterPro IPR000780; KEGG: pca:Pcar_1199 methylase of chemotaxis methyl-accepting protein, CheR-like; PFAM: MCP methyltransferase CheR-type; PRIAM: Protein-glutamate O-methyltransferase; SMART: MCP methyltransferase CheR-type; SPTR: MCP methyltransferase, CheR-type; PFAM: CheR methyltransferase, SAM binding domain; CheR methyltransferase, all-alpha domain.
  
 0.994
ADK83084.1
Putative CheA signal transduction histidine kinase; COGs: COG0643 Chemotaxis protein histidine kinase and related kinase; InterPro IPR008207; KEGG: ppg:PputGB1_3907 CheA signal transduction histidine kinase; PFAM: Hpt domain protein; SMART: Hpt domain protein; SPTR: Probable chemotaxis sensor histidine kinase protein; PFAM: Hpt domain.
 
 0.994
ADK80948.1
MCP methyltransferase, CheR-type; COGs: COG1352 Methylase of chemotaxis methyl-accepting protein; InterPro IPR000780; KEGG: gbm:Gbem_1595 MCP methyltransferase, CheR-type; PFAM: MCP methyltransferase CheR-type; PRIAM: Protein-glutamate O-methyltransferase; SMART: MCP methyltransferase CheR-type; SPTR: MCP methyltransferase, CheR-type; PFAM: CheR methyltransferase, SAM binding domain; CheR methyltransferase, all-alpha domain.
  
 0.978
cheD-2
CheD; Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis; Belongs to the CheD family.
 
  
 0.976
ADK80703.1
Flagellar motor switch protein FliN; FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation. Belongs to the FliN/MopA/SpaO family.
  
  
 0.966
Your Current Organism:
Sediminispirochaeta smaragdinae
NCBI taxonomy Id: 573413
Other names: S. smaragdinae DSM 11293, Sediminispirochaeta smaragdinae DSM 11293, Spirochaeta smaragdinae DSM 11293
Server load: low (14%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.