STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ADK82058.1COGs: COG2818 3-methyladenine DNA glycosylase; InterPro IPR005019; KEGG: tit:Thit_0082 DNA-3-methyladenine glycosylase I; PFAM: methyladenine glycosylase; PRIAM: DNA-3-methyladenine glycosylase I; SPTR: DNA-3-methyladenine glycosylase I; manually curated; PFAM: Methyladenine glycosylase; TIGRFAM: DNA-3-methyladenine glycosylase I. (194 aa)    
Predicted Functional Partners:
ADK81528.1
COGs: COG0519 GMP synthase PP-ATPase domain/subunit; InterProIPR000991:IPR001962:IPR001674:IPR017926:IPR 004739; KEGG: aae:aq_236 GMP synthase; PFAM: GMP synthase domain protein; glutamine amidotransferase class-I; asparagine synthase; SPTR: GMP synthase; TIGRFAM: GMP synthase, large subunit; GMP synthase, small subunit; PFAM: GMP synthase C terminal domain; Glutamine amidotransferase class-I; Asparagine synthase; TIGRFAM: GMP synthase (glutamine-hydrolyzing), C-terminal domain or B subunit; GMP synthase (glutamine-hydrolyzing), N-terminal domain or A subunit.
      0.698
ADK82101.1
methylated-DNA/protein- cysteinemethyltransferase; Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated.
    
 0.666
polA
DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.
  
  
 0.626
ADK82057.1
Cl- channel voltage-gated family protein; COGs: COG0038 Chloride channel protein EriC; InterPro IPR001807:IPR006037; KEGG: drm:Dred_2944 Cl-channel, voltage-gated family protein; PFAM: Cl- channel voltage-gated family protein; TrkA-C domain protein; SPTR: Cl-channel, voltage-gated family protein; PFAM: Voltage gated chloride channel; TrkA-C domain.
       0.578
ADK83169.1
Short-chain dehydrogenase/reductase SDR; COGs: COG4221 Short-chain alcohol dehydrogenase of unknown specificity; InterPro IPR002198:IPR002347; KEGG: pjd:Pjdr2_1690 short chain dehydrogenase; PFAM: short-chain dehydrogenase/reductase SDR; SPTR: Short-chain dehydrogenase/reductase SDR; PFAM: short chain dehydrogenase; Belongs to the short-chain dehydrogenases/reductases (SDR) family.
      0.527
ADK81874.1
COGs: COG0527 Aspartokinase; InterProIPR001341:IPR001048:IPR002912:IPR005106:IPR 001342:IPR011147:IPR001412:IPR019811; KEGG: sru:SRU_0691 bifunctional aspartokinase I/homeserine dehydrogenase I; PFAM: homoserine dehydrogenase; homoserine dehydrogenase NAD-binding; aspartate/glutamate/uridylate kinase; amino acid-binding ACT domain protein; SPTR: Bifunctional aspartokinase/homoserine dehydrogenase I; TIGRFAM: aspartate kinase; PFAM: Homoserine dehydrogenase, NAD binding domain; Homoserine dehydrogenase; ACT domain; Amino acid kinase family; TIGRFAM: glutamate--cysteine ligase/gamma-glut [...]
  
    0.413
Your Current Organism:
Sediminispirochaeta smaragdinae
NCBI taxonomy Id: 573413
Other names: S. smaragdinae DSM 11293, Sediminispirochaeta smaragdinae DSM 11293, Spirochaeta smaragdinae DSM 11293
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.